| Title: | Genetic correlates of vitamin D-binding protein and 25-hydroxyvitamin D in neonatal dried blood spots |
| Journal: | Nature Communications |
| Published: | 15 Feb 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36792583/ |
| DOI: | https://doi.org/10.1038/s41467-023-36392-5 |
| URL: | https://www.nature.com/articles/s41467-023-36392-5.pdf |
| Citations: | 13 (13 in last 2 years) as of 8 Aug 2024 |
Publication 11091
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Abstract
The vitamin D binding protein (DBP), encoded by the group-specific component (GC) gene, is a component of the vitamin D system. In a genome-wide association study of DBP concentration in 65,589 neonates we identify 26 independent loci, 17 of which are in or close to the GC gene, with fine-mapping identifying 2 missense variants on chromosomes 12 and 17 (within SH2B3 and GSDMA, respectively). When adjusted for GC haplotypes, we find 15 independent loci distributed over 10 chromosomes. Mendelian randomization analyses identify a unidirectional effect of higher DBP concentration and (a) higher 25-hydroxyvitamin D concentration, and (b) a reduced risk of multiple sclerosis and rheumatoid arthritis. A phenome-wide association study confirms that higher DBP concentration is associated with a reduced risk of vitamin D deficiency. Our findings provide valuable insights into the influence of DBP on vitamin D status and a range of health outcomes.</p>
21 Authors
- Clara Albiñana
- Zhihong Zhu
- Nis Borbye-Lorenzen
- Sanne Grundvad Boelt
- Arieh S. Cohen
- Kristin Skogstrand
- Naomi R. Wray
- Joana A. Revez
- Florian Privé
- Liselotte V. Petersen
- Cynthia M. Bulik
- Oleguer Plana-Ripoll
- Katherine L. Musliner
- Esben Agerbo
- Anders D. Børglum
- David M. Hougaard
- Merete Nordentoft
- Thomas Werge
- Preben Bo Mortensen
- Bjarni J. Vilhjálmsson
- John J. McGrath
1 Application
| Application ID | Title |
|---|---|
| 12505 | Dissecting the genetic basis of relationships between early-life and later-life events |
Enabling scientific discoveries that improve human health