| Title: | The Causal Association of Irritable Bowel Syndrome with Multiple Disease Outcomes: A Phenome-Wide Mendelian Randomization Study |
| Journal: | Journal of Clinical Medicine |
| Published: | 31 Jan 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36769754/ |
| DOI: | https://doi.org/10.3390/jcm12031106 |
| URL: | https://www.mdpi.com/2077-0383/12/3/1106/pdf?version=1675154986 |
Publication 11018
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Abstract
BACKGROUND: This study aimed to identify novel associations between irritable bowel syndrome (IBS) and a broad range of outcomes.</p>
METHODS: In total, 346,352 white participants in the U.K. Biobank were randomly divided into two halves, in which a genome-wide association study (GWAS) of IBS and a polygenic risk score (PRS) analysis of IBS using GWAS summary statistics were conducted, respectively. A phenome-wide association study (PheWAS) based on the PRS of IBS was performed to identify disease outcomes associated with IBS. Then, the causalities of these associations were tested by both one-sample (individual-level data in U.K. Biobank) and two-sample (publicly available summary statistics) Mendelian randomization (MR). Sex-stratified PheWAS-MR analyses were performed in male and female, separately.</p>
RESULTS: Our PheWAS identified five diseases associated with genetically predicted IBS. Conventional MR confirmed these causal associations between IBS and depression (OR: 1.07, 95%CI: 1.01-1.14, p = 0.02), diverticular diseases of the intestine (OR: 1.13, 95%CI: 1.08-1.19, p = 3.00 × 10-6), gastro-esophageal reflux disease (OR: 1.09, 95%CI: 1.05-1.13, p = 3.72 × 10-5), dyspepsia (OR: 1.21, 95%CI: 1.13-1.30, p = 9.28 × 10-8), and diaphragmatic hernia (OR: 1.10, 95%CI: 1.05-1.15, p = 2.75 × 10-5). The causality of these associations was observed in female only, but not men.</p>
CONCLUSIONS: Increased risks of IBS is found to cause a series of disease outcomes. Our findings support further investigation on the clinical relevance of increased IBS risks with mental and digestive disorders.</p>
9 Authors
- Chunyang Li
- Yilong Chen
- Yi Chen
- Zhiye Ying
- Yao Hu
- Yalan Kuang
- Huazhen Yang
- Huan Song
- Xiaoxi Zeng
1 Application
| Application ID | Title |
|---|---|
| 54803 | Deciphering complex traits - phenotypic and genetic associations between traits in the UK Biobank Cohort |
Enabling scientific discoveries that improve human health