| Title: | Association of COVID-19 with short- and long-term risk of cardiovascular disease and mortality: a prospective cohort in UK Biobank |
| Journal: | Cardiovascular Research |
| Published: | 19 Jan 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36652991/ |
| DOI: | https://doi.org/10.1093/cvr/cvac195 |
| URL: | https://academic.oup.com/cardiovascres/advance-article-pdf/doi/10.1093/cvr/cvac195/48715984/cvac195.pdf |
Publication 10987
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Abstract
AIMS: This study aims to evaluate the short- and long-term associations between COVID-19 and development of cardiovascular disease (CVD) outcomes and mortality in the general population.</p>
METHODS AND RESULTS: A prospective cohort of patients with COVID-19 infection between 16 March 2020 and 30 November 2020 was identified from UK Biobank, and followed for up to 18 months, until 31 August 2021. Based on age (within 5 years) and sex, each case was randomly matched with up to 10 participants without COVID-19 infection from two cohorts-a contemporary cohort between 16 March 2020 and 30 November 2020 and a historical cohort between 16 March 2018 and 30 November 2018. The characteristics between groups were further adjusted with propensity score-based marginal mean weighting through stratification. To determine the association of COVID-19 with CVD and mortality within 21 days of diagnosis (acute phase) and after this period (post-acute phase), Cox regression was employed. In the acute phase, patients with COVID-19 (n = 7584) were associated with a significantly higher short-term risk of CVD {hazard ratio (HR): 4.3 [95% confidence interval (CI): 2.6- 6.9]; HR: 5.0 (95% CI: 3.0-8.1)} and all-cause mortality [HR: 81.1 (95% CI: 58.5-112.4); HR: 67.5 (95% CI: 49.9-91.1)] than the contemporary (n = 75 790) and historical controls (n = 75 774), respectively. Regarding the post-acute phase, patients with COVID-19 (n = 7139) persisted with a significantly higher risk of CVD in the long-term [HR: 1.4 (95% CI: 1.2-1.8); HR: 1.3 (95% CI: 1.1- 1.6)] and all-cause mortality [HR: 5.0 (95% CI: 4.3-5.8); HR: 4.5 (95% CI: 3.9-5.2) compared to the contemporary (n = 71 296) and historical controls (n = 71 314), respectively.</p>
CONCLUSIONS: COVID-19 infection, including long-COVID, is associated with increased short- and long-term risks of CVD and mortality. Ongoing monitoring of signs and symptoms of developing these cardiovascular complications post diagnosis and up till at least a year post recovery may benefit infected patients, especially those with severe disease.</p>
11 Authors
- Eric Yuk Fai Wan
- Sukriti Mathur
- Ran Zhang
- Vincent Ka Chun Yan
- Francisco Tsz Tsun Lai
- Celine Sze Ling Chui
- Xue Li
- Carlos King Ho Wong
- Esther Wai Yin Chan
- Kai Hang Yiu
- Ian Chi Kei Wong
1 Application
| Application ID | Title |
|---|---|
| 65688 | Understanding the impact and risk factors associated with non-communicable diseases (NCDs) |
Enabling scientific discoveries that improve human health