| Title: | Mediation Effect of Brain Volume on the Relationship Between Peripheral Inflammation and Cognitive Decline. |
| Journal: | Journal of Alzheimer's Disease |
| Published: | 1 Jan 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37545239/ |
| DOI: | https://doi.org/10.3233/jad-230253 |
Publication 10886
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Abstract
BACKGROUND: Studies have reported the associations between inflammation, brain volume, and cognition separately. It is reasonable to assume peripheral inflammation may contribute to cognitive decline through brain volume atrophy.</p>
OBJECTIVE: To examine the associations between peripheral inflammation, brain volume, and cognition among adults, and to investigate whether brain volume atrophy mediates the inflammation-cognition relationshipMethods:We retrieved 20,381 participants with available data on peripheral inflammation, brain volume, and cognition from the UK Biobank cohort. Cognitive function was assessed by performance on cognitive tasks probing various cognitive domains. Brain volumes were measured by magnetic resonance imaging (MRI). Multivariable linear models were used to investigate the associations between three peripheral inflammatory indexes (C-reactive protein, systemic immune-inflammatory index, neutrophil-to-lymphocyte ratio), brain volume, and cognition. Mediation analyses were conducted to assess the potential mediating effect of brain volume atrophy. All results were corrected for multiple comparisons using the false-discovery rate (FDR).</p>
RESULTS: Peripheral inflammation was inversely associated with grey matter volume (GMV), white matter volume (WMV), and cognition after adjusting for potential covariates. For instance, CRP was associated with the GMV of left parahippocampal gyrus (β= -0.05, 95% confidence interval [CI]: -0.06 to -0.04, pFDR =1.07×10-16) and general cognitive factor (β= -0.03, 95% CI: -0. -0.04 to -0.01, pFDR = 0.001). Brain volume atrophy mediated the inflammation-cognitive decline relationship, accounting for 15-29% of the overall impact.</p>
CONCLUSION: In this cohort study, peripheral inflammation was associated with brain volume atrophy and cognitive decline. Brain atrophy may mediate the inflammation-cognitive decline relationship.</p>
9 Authors
- Bingting Zhuo
- Dashan Zheng
- Miao Cai
- Chongjian Wang
- Shiyu Zhang
- Zilong Zhang
- Fei Tian
- Xiaojie Wang
- Hualiang Lin
1 Application
| Application ID | Title |
|---|---|
| 69550 | Identifying the potential effects of environmental and other healthcare related factors influencing health outcomes, mediated by genetic variances |
Enabling scientific discoveries that improve human health