| Title: | Diet and Risk of Non-Alcoholic Fatty Liver Disease, Cirrhosis, and Liver Cancer: A Large Prospective Cohort Study in UK Biobank |
| Journal: | Nutrients |
| Published: | 15 Dec 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36558494/ |
| DOI: | https://doi.org/10.3390/nu14245335 |
| Citations: | 28 (28 in last 2 years) as of 8 Aug 2024 |
Publication 10825
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Background and Aims: Epidemiological evidence has shown the association between nutritional habits and liver disease. However, results remain conflicting. This study investigated the influence of dietary factors on the risk of incident non-alcoholic fatty liver disease (NAFLD), cirrhosis, and liver cancer. Methods: Data from the UK Biobank database were analyzed (n = 372,492). According to baseline data from the food frequency questionnaire, two main dietary patterns (Western and prudent) were identified using principal component analysis. We used cox proportional hazards models to explore the associations of individual food groups and dietary patterns with NAFLD, cirrhosis, and liver cancer. Results: During a median follow-up of 12 years, 3527 hospitalized NAFLD, 1643 cirrhosis, and 669 liver cancer cases were recorded among 372,492 participants without prior history of cancer or chronic liver diseases at baseline. In multivariable adjusted analysis, participants in the high tertile of Western dietary pattern score had an 18% (95%CI = 1.09−1.29), 21% (95%CI = 1.07−1.37), and 24% (95%CI = 1.02−1.50) higher risk of incident NAFLD, liver cirrhosis, and liver cancer, respectively, compared with the low tertile. Participants in the high tertile of prudent scores had a 15% (95%CI = 0.75−0.96) lower risk of cirrhosis, as compared with those in the low tertile. In addition, the higher consumption of red meat and the lower consumption of fruit, cereal, tea, and dietary fiber were significantly associated with a higher risk of NAFLD, cirrhosis, and liver cancer (ptrend < 0.05). Conclusions: This large prospective cohort study showed that an increased intake of food from the Western dietary pattern could be correlated with an increased risk of chronic liver diseases, while the prudent pattern was only correlated with a reduced liver cirrhosis risk. These data may provide new insights into lifestyle interventions for the prevention of chronical liver diseases.</p>
10 Keywords
- Biological Specimen Banks
- Diet
- Diet, Western
- Humans
- Liver Cirrhosis
- Liver Neoplasms
- Non-alcoholic Fatty Liver Disease
- Prospective Studies
- Risk Factors
- United Kingdom
9 Authors
- Wen Guo
- Xinyuan Ge
- Jing Lu
- Xin Xu
- Jiaxin Gao
- Quanrongzi Wang
- Ci Song
- Qun Zhang
- Chengxiao Yu
1 Application
| Application ID | Title |
|---|---|
| 85248 | The interaction effects of genetic susceptibility and life exposures on human metabolomics and liver diseases risk and related mortality |
Enabling scientific discoveries that improve human health