| Title: | Associations of physical activity intensity with incident cardiovascular diseases and mortality among 366,566 UK adults |
| Journal: | International Journal of Behavioral Nutrition and Physical Activity |
| Published: | 13 Dec 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36514169/ |
| DOI: | https://doi.org/10.1186/s12966-022-01393-y |
| URL: | https://ijbnpa.biomedcentral.com/counter/pdf/10.1186/s12966-022-01393-y |
Publication 10813
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Abstract
Abstract</p>
BackgroundThe associations of the proportion of vigorous physical activity (VPA) to moderate to vigorous physical activity (MVPA) with incident cardiovascular disease (CVD) and all-cause mortality are unclear.MethodsThe present study included 366,566 participants (aged 40-69 years) without baseline CVD from the UK biobank during 2006 to 2010. Cox regression was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for risks of outcomes.ResultsDuring a median 11.8 years of follow-up, among 366,566 participants (mean age [SD]: 56.0 [8.1]), 31,894 incident CVD and 19,823 total deaths were documented. Compared with no VPA, 0%-30% of VPA to MVPA was associated with 12% and 19% lower risks of incident CVD (HR, 0.88 [95% CI, 0.86-0.91]) and all-cause mortality (HR, 0.81 [95% CI, 0.78-0.84]), respectively. Furthermore, we found that the maximum reduction of risks of incident CVD and all-cause mortality occurred at performing approximately 30% of VPA to MVPA (P < 0.001). Compared with participants reporting the lowest levels of MVPA (moderate physical activity [MPA], 0-150 min/week; VPA, 0-75 min/week), those performing 150-300 min/week of MPA and ≥ 150 min/week of VPA experienced the lowest risk of incident CVD (HR, 0.87 [95% CI, 0.79-0.95]) and all-cause mortality (HR, 0.71 [95% CI, 0.63-0.80]). Interestingly, we found that smokers yielded more cardiovascular benefits than non-smokers by performing a higher volume of VPA.ConclusionsComparing with UK adults reporting no VPA, engaging in 30% of VPA was associated with the lowest risk of incident CVD and all-cause mortality.</p>
7 Authors
- Xuanwen Mu
- Shuangyan Liu
- Mingjian Fu
- Mengyun Luo
- Ding Ding
- Liangkai Chen
- Kuai Yu
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