| Title: | Individual frailty phenotype components and mortality in adults with type 2 diabetes: A UK Biobank study |
| Journal: | Diabetes Research and Clinical Practice |
| Published: | 24 Nov 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36427627/ |
| DOI: | https://doi.org/10.1016/j.diabres.2022.110155 |
| URL: | http://www.diabetesresearchclinicalpractice.com/article/S016882272200969X/pdf |
Publication 10719
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Abstract
AIMS: This study aimed to explore associations between frailty components and mortality and rank prognostic relevance of each frailty component in predicting mortality in adults with and without type 2 diabetes (T2D).</p>
METHODS: We used data from the UK Biobank. Associations and prognostic discrimination of individual Fried's frailty components and the overall frailty status with all-cause and cardiovascular (CVD) mortality were investigated using Cox proportional-hazard models and C-index in adults with and without T2D.</p>
RESULTS: In both populations the strongest association with all-cause mortality across all frailty components and overall frailty status was observed for slow walking pace (without T2D Hazard Ratio [HR] 2.25, 95 %CI: 2.12-2.38 and with T2D HR 1.95, 95 %CI: 1.67-2.28). Similarly, slow walking pace was associated with a greater risk of CVD mortality. The combination of T2D and slow walking pace had the strongest association with all-cause and CVD mortality, compared to the combination of T2D and other frailty components or overall frailty status. Slow walking pace also provided the greatest prognostic discrimination.</p>
CONCLUSION: Slow walking pace has a stronger predictive factor for all-cause and CVD mortality compared to other frailty components and overall frailty status, especially when simultaneously present with T2D.</p>
11 Authors
- Monika Mickute
- Francesco Zaccardi
- Cameron Razieh
- Jack Sargeant
- Alice C Smith
- Thomas J Wilkinson
- Hannah M L Young
- David Webb
- Kamlesh Khunti
- Melanie J Davies
- Thomas Yates
1 Application
| Application ID | Title |
|---|---|
| 52553 | Sarcopenia in chronic kidney disease and diabetes mellitus: a UK Biobank study |
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