| Title: | Duration of Diabetes, Glycemic Control, and Risk of Heart Failure Among Adults With Diabetes: A Cohort Study |
| Journal: | The Journal of Clinical Endocrinology & Metabolism |
| Published: | 16 Nov 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36383477/ |
| DOI: | https://doi.org/10.1210/clinem/dgac642 |
| Citations: | 6 (5 in last 2 years) as of 8 Aug 2024 |
Publication 10689
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Abstract
CONTEXT: The influences of diabetes duration and glycemic control and their potential interplays on the risk of heart failure (HF) remain unclear.</p>
OBJECTIVE: This work aimed to investigate the association of diabetes duration and glycemic control with the risk of HF.</p>
METHODS: A total of 23 754 individuals with diabetes but without HF during the baseline recruitment of UK Biobank were included in this study. Duration of diabetes was self-reported, and the status of glycemic control was reflected by glycated hemoglobin A1c (HbA1c) levels. Their associations with incident HF were assessed using multivariate Cox models adjusting for traditional risk factors.</p>
RESULTS: Duration of diabetes and HbA1c levels both were positively associated with the risk of HF. The hazard ratios (HRs) (95% CI) for diabetes durations of 5 to less than 10, 10 to less than 15, and 15 years or more were 1.09 (0.97-1.23), 1.13 (0.97-1.30), and 1.32 (1.15-1.53), respectively (vs < 5 years); and the HRs for HbA1c of 53.0 to less than 58.5 mmol/mol (7.0% to < 7.5%), 58.5 to less than 63.9 mmol/mol (7.5% to < 8.0%), and 63.9 mmol/mol or greater (8.0%) were 1.15 (1.02-1.31), 1.07 (0.91-1.26), and 1.46 (1.30-1.65), respectively (vs < 53.0 mmol/mol [7.0%]). Individuals with the longest disease duration (≥ 15 years) and poorer glycemic control (HbA1c ≥ 63.9 mmol/mol [8.0%]) had a particularly higher risk of HF (P for interaction = .026).</p>
CONCLUSION: The risk of HF among individuals with diabetes increases with a longer duration of diabetes and increasing HbA1c levels. This finding may contribute to the individualized prevention of HF in patients with diabetes if being considered in clinical practices and policy-making.</p>
9 Keywords
- Adult
- Blood Glucose
- Cohort Studies
- Diabetes Mellitus, Type 2
- Glycated Hemoglobin
- Glycemic Control
- Heart Failure
- Humans
- Risk Factors
8 Authors
- Huan-Huan Yang
- Fu-Rong Li
- Ze-Kun Chen
- Meng-Ge Zhou
- Li-Feng Xie
- Yuan-Yuan Jin
- Zhi-Hui Li
- Guo-Chong Chen
1 Application
| Application ID | Title |
|---|---|
| 55794 | Biomarkers, lifestyle and body composition in relation to healthy aging |
Enabling scientific discoveries that improve human health