| Title: | A General Cognitive Ability Factor for the UK Biobank |
| Journal: | Behavior Genetics |
| Published: | 15 Nov 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36378351/ |
| DOI: | https://doi.org/10.1007/s10519-022-10127-6 |
| URL: | https://hal.science/hal-03856587/file/G_Factor_Manuscript_PsyArXiv-1.pdf |
Publication 10685
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Abstract
UK Biobank participants do not have a high-quality measure of intelligence or polygenic scores (PGSs) of intelligence to simultaneously examine the genetic and neural underpinnings of intelligence. We created a standardized measure of general intelligence (g factor) relative to the UK population and estimated its quality. After running a GWAS of g on UK Biobank participants with a g factor of good quality and without neuroimaging data (N = 187,288), we derived a g PGS for UK Biobank participants with neuroimaging data. For individuals with at least one cognitive test, the g factor from eight cognitive tests (N = 501,650) explained 29% of the variance in cognitive test performance. The PGS for British individuals with neuroimaging data (N = 27,174) explained 7.6% of the variance in g. We provided high-quality g factor estimates for most UK Biobank participants and g factor PGSs for UK Biobank participants with neuroimaging data.</p>
5 Authors
- Camille Michèle Williams
- Ghislaine Labouret
- Tobias Wolfram
- Hugo Peyre
- Franck Ramus
1 Application
| Application ID | Title |
|---|---|
| 46007 | Brain allometry and asymmetries as intermediate phenotypes between genetic and environmental factors, and cognitive function and mental health |
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