| Title: | Estimation and predictors of the Omega-3 Index in the UK Biobank |
| Journal: | British Journal Of Nutrition |
| Published: | 10 Oct 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36210531/ |
| DOI: | https://doi.org/10.1017/s0007114522003282 |
| URL: | ~Ehttps://www.cambridge.org/core/services/aop-cambridge-core/content/view/6EAB77B97E57BAF143443039043A3CD9/S0007114522003282a.pdf/div-class-title-estimation-and-predictors-of-the-omega-3-index-in-the-uk-biobank-div.pdf~ |
Publication 10555
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Abstract
Information on the Omega-3 Index (O3I) in the United Kingdom (UK) is scarce. The UK-Biobank (UKBB) contains data on total plasma n3-PUFA% and DHA% measured by NMR. The aim of our study was to create an equation to estimate the O3I (eO3I) from these data. We first performed an inter-laboratory experiment with 250 random blood samples in which the O3I was measured in erythrocytes by GC, and total n3 % and DHA% were measured in plasma by NMR. The best predictor of eO3I included both DHA% and a derived metric, the total n3 %-DHA%. Together these explained 65 % of the variability (r = 0·832, P < 0·0001). We then estimated the O3I in 117 108 UKBB subjects and correlated it with demographic and lifestyle variables in multivariable-adjusted models. The mean eO3I was 5·58 % (sd 2·35 %) in this UKBB cohort. Several predictors were significantly correlated with eO3I (all P < 0·0001). In general order of impact and with directionality (-, inverse and +, direct): oily-fish consumption (+), fish oil supplement use (+), female sex (+), older age (+), alcohol use (+), smoking (-), higher waist circumference and BMI (-), lower socioeconomic status and less education (-). Only 20·5 % of eO3I variability could be explained by predictors investigated, and oily fish consumption accounted for 7·0 % of that. With the availability of the eO3I in the UKBB cohort, we will be in a position to link risk for a variety of diseases with this commonly used and well-documented marker of n3-PUFA biostatus.</p>
4 Authors
- Jan Philipp Schuchardt
- Nathan Tintle
- Jason Westra
- William S. Harris
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