| Title: | Association of all-cause mortality with sugar intake from different sources in the prospective cohort of UK Biobank participants |
| Journal: | British Journal Of Nutrition |
| Published: | 7 Oct 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36204988/ |
| DOI: | https://doi.org/10.1017/s0007114522003233 |
| URL: | ~Ehttps://www.cambridge.org/core/services/aop-cambridge-core/content/view/D4B5751CCED82219D8B0014B5B753487/S0007114522003233a.pdf/div-class-title-association-of-all-cause-mortality-with-sugar-intake-from-different-sources-in-the-prospective-cohort-of-uk-biobank-participants-div.pdf~ |
Publication 10551
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Abstract
The present study elucidates the association of intrinsic sugars and free sugars (FS) from all relevant sources with all-cause mortality in the prospective UK Biobank cohort. Sugar intake was assessed in 186 811 UK Biobank participants who completed at least one web-based 24-h dietary recall (Oxford WebQ). Cox proportional hazard regression models for all-cause mortality were used with sugar intake from different sources included as penalised cubic splines to allow non-linear predictor effects. Over a mean follow-up of 12·3 years, 8576 (4·6 %) deaths occurred. FS but not intrinsic sugars were significantly and dose-dependently associated with hazard ratio (HR) for all-cause mortality. The association with all-cause mortality was significant and dose dependent for FS in beverages, but not in solids with the mean (CI) HR at 50 g/d v. 0 g/d consumption at 1·10, 95 % CI (1·07, 1·14) and 1·01, 95 % CI (0·98, 1·03), respectively. Within the beverages subcategories, a significant dose-dependent association with mortality was detected for FS in soda/fruit drinks and milk-based drinks whereas this relation was NS for FS in pure juice and tea/coffee. FS in four different subtypes of solids, i.e. treats, cereals, toppings and sauces, were not positively associated with all-cause mortality. Major findings were robust in sensitivity analyses. In conclusion, only some FS sources were associated with all-cause mortality. Interventions targeting FS subtypes might be most effective concerning mortality if focused on the reduction of soda/fruit drinks and milk-based sugary drinks; however, the present results need to be confirmed by independent studies.</p>
5 Authors
- Anna Kaiser
- Sylva M. Schaefer
- Inken Behrendt
- Gerrit Eichner
- Mathias Fasshauer
1 Application
| Application ID | Title |
|---|---|
| 53438 | Association of nutrient composition with metabolic syndrome and cardiovascular risk - Findings from the UK Biobank |
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