| Title: | Modeling multivariate age-related imaging variables with dependencies |
| Journal: | Statistics in Medicine |
| Published: | 7 Jul 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36106648/ |
| DOI: | https://doi.org/10.1002/sim.9522 |
| URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9494615 |
Publication 10352
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Neuroimaging techniques have been increasingly used to understand the neural biology of aging brains. The neuroimaging variables from distinct brain locations and modalities can exhibit age-related patterns that reflect localized neural decline. However, it is a challenge to identify the impacts of risk factors (eg, mental disorders) on multivariate imaging variables while simultaneously accounting for the dependence structure and nonlinear age trajectories using existing tools. We propose a mixed-effects model to address this challenge by building random effects based on the latent brain aging status. We develop computationally efficient algorithms to estimate the parameters of new random effects. The simulations show that our approach provides accurate parameter estimates, improves the inference efficiency, and reduces the root mean square error compared to existing methods. We further apply this method to the UK Biobank data to investigate the effects of tobacco smoking on the white matter integrity of the entire brain during aging and identify the adverse effects on white matter integrity with multiple fiber tracts.</p>
5 Authors
- Hwiyoung Lee
- Chixiang Chen
- Peter Kochunov
- Liyi Elliot Hong
- Shuo Chen
Enabling scientific discoveries that improve human health