| Title: | Considering hormone-sensitive cancers as a single disease in the UK biobank reveals shared aetiology |
| Journal: | Communications Biology |
| Published: | 21 Jun 2022 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/35729236/ |
| DOI: | https://doi.org/10.1038/s42003-022-03554-y |
| URL: | https://www.nature.com/articles/s42003-022-03554-y.pdf |
| Citations: | 5 (5 in last 2 years) as of 8 Aug 2024 |
Publication 10335
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Abstract
Hormone-related cancers, including cancers of the breast, prostate, ovaries, uterine, and thyroid, globally contribute to the majority of cancer incidence. We hypothesize that hormone-sensitive cancers share common genetic risk factors that have rarely been investigated by previous genomic studies of site-specific cancers. Here, we show that considering hormone-sensitive cancers as a single disease in the UK Biobank reveals shared genetic aetiology. We observe that a significant proportion of variance in disease liability is explained by the genome-wide single nucleotide polymorphisms (SNPs), i.e., SNP-based heritability on the liability scale is estimated as 10.06% (SE 0.70%). Moreover, we find 55 genome-wide significant SNPs for the disease, using a genome-wide association study. Pair-wise analysis also estimates positive genetic correlations between some pairs of hormone-sensitive cancers although they are not statistically significant. Our finding suggests that heritable genetic factors may be a key driver in the mechanism of carcinogenesis shared by hormone-sensitive cancers.</p>
7 Authors
- Muktar Ahmed
- Ville-Petteri Mäkinen
- Anwar Mulugeta
- Jisu Shin
- Terry Boyle
- Elina Hyppönen
- Sang Hong Lee
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