| Title: | Association of birth and childhood weight with risk of chronic diseases and multimorbidity in adulthood |
| Journal: | Communications Medicine |
| Published: | 31 Jul 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37524882/ |
| DOI: | https://doi.org/10.1038/s43856-023-00335-4 |
| URL: | https://www.nature.com/articles/s43856-023-00335-4.pdf |
Publication 10292
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Abstract
BackgroundLittle is known about the relationship between early life body size and occurrence of life-course multiple chronic diseases (multimorbidity). We aim to evaluate associations of birth weight, childhood body size, and their changes with the risks of chronic diseases and multimorbidity.MethodsThis prospective cohort study included 246,495 UK Biobank participants (aged 40-69 years) who reported birth weight and childhood body size at 10 years old. Birth weight was categorized into low, normal, and high; childhood body size was reported as being thinner, average, or plumper. Multimorbidity was defined as having two or more of 38 chronic conditions retrieved from inpatient hospital data until 31 December, 2020. The Cox regression and quasi-Poisson mixed effects models were used to estimate the associations.ResultsWe show that 57,071 (23.2%) participants develop multimorbidity. Low birth weight (hazard ratio [HR] 1.29, 95% confidence interval [CI] 1.26-1.33), high birth weight (HR 1.02, 95% CI > 1.00-1.05), thinner (HR 1.21, 95% CI 1.18-1.23) and plumper body size (HR 1.06, 95% CI 1.04-1.09) are associated with higher risks of multimorbidity. A U-shaped relationship between birth weight and multimorbidity is observed. Changing to be thinner or plumper is associated with multimorbidity and many conditions, compared to changing to be average.ConclusionsLow birth weight, being thinner and changing to have a thinner body size in childhood are associated with higher risks of developing multimorbidity and many chronic conditions in adulthood. Early monitoring and maintaining a normal body size in childhood could have life-course benefits for preventing multimorbidity above and beyond individual conditions.</p>
7 Authors
- Yue Zhang
- Yaguan Zhou
- Yangyang Cheng
- Rodrigo M. Carrillo-Larco
- Muhammad Fawad
- Shu Chen
- Xiaolin Xu
1 Application
| Application ID | Title |
|---|---|
| 66354 | Investigating the genetic, environmental and clinical determinants and their interactions on cancer risk, and developing risk prediction and prognosis models for common cancer types |
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