| Title: | Associations of dietary patterns, ultra-processed food and nutrient intake with incident atrial fibrillation |
| Journal: | Heart |
| Published: | 17 Jul 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37460193/ |
| DOI: | https://doi.org/10.1136/heartjnl-2023-322412 |
Publication 10290
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Abstract
OBJECTIVE: To examine the associations between specific dietary patterns and incident atrial fibrillation (AF).</p>
METHODS: Using data from the UK Biobank, dietary intakes were calculated from 24-hour diet recall questionnaires. Indices representing adherence to dietary patterns (Mediterranean-style, Dietary Approaches to Stop Hypertension (DASH) and plant-based diets) were scored, and ultra-processed food consumption was studied as a percentage of total food mass consumed. Incident AF hospitalisations were assessed in Cox regression models.</p>
RESULTS: A total of 121 300 individuals were included, with 4 579 incident AF cases over a median follow-up of 8.8 years. Adherence to Mediterranean-style or DASH diets was associated with a lower incidence of AF in minimally adjusted analyses (HR for highest vs lowest quintile 0.87 (95% CI 0.80-0.96) and HR 0.78 (95% CI 0.71-0.86), respectively). However, associations were no longer significant after accounting for lifestyle factors (HR 0.95 (95% CI 0.87-1.04) and 0.94 (95% CI 0.86-1.04) respectively), with adjustment for body mass index responsible for approximately three-quarters of the effect size attenuation. Plant-based diets were not associated with AF risk in any models. Greatest ultra-processed food consumption was associated with a significant increase in AF risk even in fully adjusted models (HR 1.13 (95% CI 1.02-1.24)), and a 10% increase in absolute intake of ultra-processed food was associated with a 5% increase in AF risk (HR 1.05 (95% CI 1.01-1.08)).</p>
CONCLUSION: With the possible exception of reducing ultra-processed food consumption, these findings suggest that attention to other modifiable risk factors, particularly obesity, may be more important than specific dietary patterns for the primary prevention of AF.</p>
12 Authors
- Samuel J Tu
- Celine Gallagher
- Adrian D Elliott
- Kathryn E Bradbury
- Gregory M Marcus
- Dominik Linz
- Bradley M Pitman
- Melissa E Middeldorp
- Jeroen M Hendriks
- Dennis H Lau
- Prashanthan Sanders
- Christopher X Wong
1 Application
| Application ID | Title |
|---|---|
| 62306 | Associations of cardiometabolic, genetic, and lifestyle factors with the risk of arrhythmias |
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