| Title: | Variety and Duration of Different Sedentary Behaviors, Inflammation, Genetic Susceptibility, and New-Onset Dementia in the Older Population |
| Journal: | Journal of the American Medical Directors Association |
| Published: | 11 Jul 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37451311/ |
| DOI: | https://doi.org/10.1016/j.jamda.2023.06.003 |
Publication 10262
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Abstract
OBJECTIVES: We aimed to evaluate the relationship of the variety and duration of different sedentary behaviors (TV-watching, driving, and nonoccupational computer use) with the risk of dementia in older participants, and examine whether inflammation and genetic susceptibility may modify the relationship.</p>
DESIGN: A prospective cohort study.</p>
SETTING AND PARTICIPANTS: 173,829 older participants (≥60 years) without prior dementia in the UK Biobank were enrolled.</p>
METHODS: A healthy sedentary behavior score was calculated as the number of the 3 major sedentary behaviors with a duration associated with the lowest risk of dementia. The primary outcome was new-onset all-cause dementia.</p>
RESULTS: During a median follow-up of 12.4 years, 4965 (2.9%) participants developed new-onset dementia. There were U-shaped associations for TV-watching and driving time, and a reversed J-shaped association for nonoccupational computer use time with new-onset all-cause dementia, with the lowest dementia risk at >0-<2 hours/day for all the 3 sedentary behaviors. Moreover, a higher healthy sedentary behavior score was significantly associated with a lower risk of all-cause dementia (per 1 score increment: hazard ratio 0.78, 95% CI 0.75-0.81), with a stronger inverse association in those with higher levels of high-sensitivity C-reactive protein and monocytes (both P-interactions <.05). Genetic risks of dementia did not significantly modify the association. Similar trends were found for new-onset Alzheimer's disease and vascular dementia.</p>
CONCLUSIONS AND IMPLICATIONS: The associations between the duration of different sedentary behaviors and new-onset dementia were different in the older population. Moreover, the variety of sedentary behavior was inversely associated with new-onset dementia, especially among those with higher levels of inflammation.</p>
10 Authors
- Sisi Yang
- Ziliang Ye
- Mengyi Liu
- Yanjun Zhang
- Xiaoqin Gan
- Qimeng Wu
- Chun Zhou
- Panpan He
- Yuanyuan Zhang
- Xianhui Qin
1 Application
| Application ID | Title |
|---|---|
| 73201 | Identification of residual risks of non-infectious chronic diseases |
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