| Title: | Association between coffee and incident heart failure: A prospective cohort study from the UK Biobank |
| Journal: | Nutrition Metabolism and Cardiovascular Diseases |
| Published: | 11 Jul 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37563067/ |
| DOI: | https://doi.org/10.1016/j.numecd.2023.07.011 |
Publication 10261
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Abstract
BACKGROUND AND AIMS: The relationship between coffee consumption and heart failure (HF) incidence is inconclusive. This study aimed to explore the association between time-varying coffee consumption and incident HF using a longitudinal study design.</p>
METHODS AND RESULTS: Data were obtained from the UK Biobank, comprising 497,503 adults (age, 56.5 ± 8.1 years; 54.6% women) who were free from HF at baseline in 2006-2010. The median follow-up time for the HF incidence was 11.9 years. Marginal structural models (MSM) were employed to adjust for potential time-varying confounders and account for bias caused by loss of follow-up. Furthermore, we used a restricted cubic spline to test and describe the nonlinear relationship between coffee consumption and HF risk. At baseline, 70.5% of participants reported drinking ≥1 cups/d coffee and 2.7% participants developed HF. After adjusting for potential confounders, we identified a nonlinear J-shaped association between coffee consumption and HF risk (P < 0.001). Compared with drinking coffee <1 cups/d, 1-2 cups/d (HR = 0.878; 95% CI: 0.838-0.920), 3-4 cups/d (HR = 0.920; 95% CI: 0.869-0.974) may be associated with a reduced risk of HF, while >6 cups/d (HR = 1.209; 95% CI: 1.056-1.385) may be associated with a higher risk of HF. However, sensitive analyses stratified by gender and smoking status indicated that >6 cups/d does not significantly increase the risk of HF. Additionally, the type of coffee was found to significant impact on the incidence of HF (P < 0.05).</p>
CONCLUSION: In this large cohort of UK adults, moderate coffee consumption may reduce risk of HF incidence.</p>
11 Authors
- Qiang Han
- Jiadong Chu
- Wei Hu
- Siyuan Liu
- Na Sun
- Xuanli Chen
- Qida He
- Zhaolong Feng
- Tongxing Li
- Jun Wu
- Yueping Shen
1 Application
| Application ID | Title |
|---|---|
| 68136 | Prediction of the risk of morbidity, recurrence and mortality of cardiovascular diseases and cancer: the effect of environmental, clinical and genetic factors |
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