| Title: | Association Between Glucosamine Use and the Risk of Incident Heart Failure The UK Biobank Cohort Study and Mendelian Randomization Analysis |
| Journal: | Mayo Clinic Proceedings |
| Published: | 7 Jul 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37422736/ |
| DOI: | https://doi.org/10.1016/j.mayocp.2023.04.019 |
Publication 10247
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Abstract
OBJECTIVE: To evaluate the association between regular glucosamine intake and heart failure (HF) and to explore whether the association is mediated by relevant cardiovascular disease.</p>
PATIENTS AND METHODS: We included 479,650 participants with data available for supplement use and without HF at baseline from the UK Biobank study. Using 12 single-nucleotide polymorphisms linked to HF, a weighted genetic risk score was calculated. We evaluated the association between glucosamine use and HF by Cox regression models after inverse probability of treatment weighting. A validation and mediation analysis were performed through two-sample Mendelian randomization. The study was from May 18, 2006, to February 16, 2018.</p>
RESULTS: During a median follow-up of 9.0 (IQR, 8.3-9.8) years, we documented 5501 incident cases of HF. In multivariable analysis, the HR of glucosamine users for HF was 0.87 (95% CI, 0.81 to 0.94). The inverse associations were stronger in males and participants with unfavorable lifestyle (P<.05 for interaction). Genetic risk categories did not modify this association (P>.05 for interaction). Multivariable Mendelian randomization showed that taking glucosamine was protective against HF (HR, 0.92; 95% CI, 0.87 to 0.96). The mediated proportion of coronary heart disease and stroke were 10.5% (95% CI, 7.6% to 13.4%) and 14.4% (95% CI, 10.8% to 18.0%), respectively. The two-mediator combination accounted for 22.7% (95% CI, 17.2% to 28.2%) of the effect of glucosamine use.</p>
CONCLUSION: Regular glucosamine supplementation was associated with a lower risk of HF regardless of genetic risk status, and to a lesser extent, coronary heart disease and stroke mediated this effect. The results may inform novel pathway for prevention and intervention toward HF.</p>
7 Authors
- Jiazhen Zheng
- Daniel Nyarko Hukportie
- Yingchai Zhang
- Jinghan Huang
- Can Ni
- Gregory Y H Lip
- Shaojun Tang
1 Application
| Application ID | Title |
|---|---|
| 97089 | Associations of physical multimorbidity patterns and heart structure with cognition and neuroimaging outcomes |
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