| Title: | Association of Serum Calcium with the Risk of Chronic Obstructive Pulmonary Disease: A Prospective Study from UK Biobank |
| Journal: | Nutrients |
| Published: | 3 Aug 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37571375/ |
| DOI: | https://doi.org/10.3390/nu15153439 |
| URL: | https://www.mdpi.com/2072-6643/15/15/3439/pdf?version=1691055698 |
Publication 10203
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Abstract
BACKGROUND: Although intracellular calcium had been demonstrated to involve in the pathogenesis of chronic obstructive pulmonary disease (COPD), the association between serum calcium and COPD risk remains unclear.</p>
METHODS: We included 386,844 participants with serum calcium measurements and without airway obstruction at the baseline from UK Biobank. The restricted cubic splines were used to assess the dose-response relationship. Multivariable cox regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the associations of albumin-corrected calcium concentrations with the risk of COPD incidence and mortality.</p>
RESULTS: During a median of 12.3 years of follow-up, 10,582 incident COPD cases were documented. A linear positive association was observed between serum calcium concentrations and the risk of COPD incidence. Compared to participants with normal serum calcium (2.19-2.56 mmol/L), a 14% higher risk of COPD was observed in hypercalcemic participants (≥2.56 mmol/L, HR = 1.14; 95% CI: 1.02-1.27). No significant effect modifications were observed in stratified variables. In survival analysis, 215 COPD-specific deaths were documented after a median survival time of 3.8 years. Compared to participants with normal serum calcium, hypercalcemic participants had a 109% (HR = 2.09, 95% CI: 1.15-3.81) increased risk for COPD-specific mortality.</p>
CONCLUSION: Our study indicated that hypercalcemia was associated with an elevated risk of COPD incidence and mortality in the European population, and suggested that serum calcium may have a potential impact on the progression of COPD.</p>
9 Authors
- Xinglin Wan
- Lulu Chen
- Zheng Zhu
- Pengfei Luo
- Dong Hang
- Jian Su
- Ran Tao
- Jinyi Zhou
- Xikang Fan
1 Application
| Application ID | Title |
|---|---|
| 84525 | Associations of serum biomarkers with chronic obstructive pulmonary disease risk and survival |
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