| Title: | Cardiovascular health, infection burden, and incident dementia in the UK Biobank |
| Journal: | Alzheimer's & Dementia |
| Published: | 7 Aug 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37547953/ |
| DOI: | https://doi.org/10.1002/alz.13405 |
Publication 10189
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Abstract
INTRODUCTION: Among older adults, total and hospitalized infection may be associated with incidence of all-cause and Alzheimer's disease (AD) dementias, with variation by cardiovascular health (CVH).</p>
METHODS: We used Cox proportional hazards (PH) models to examine the relationships between International Classification of Diseases-10th revision (ICD-10)-specific viral and bacterial infectious agents and incident all-cause and AD dementia among 355,046 UK Biobank participants ≥50 years at baseline. Life's Essential 8 (LE8) index reflected CVH.</p>
RESULTS: In both sexes, total infection burden (yes vs. no) was associated with all-cause dementia, with significant interactions by LE8 tertiles, whereby this relationship was significant only in the lowest LE8 tertile. Hospital-treated infection burden (yes vs no) was significantly related to all-cause and AD dementia, with no significant interaction with LE8 tertile. Age group patterns were detected.</p>
DISCUSSION: AD and all-cause dementia were related to hospital-treated infections, while CVH modified the relationship of total infection burden with all-cause dementia. Highlights Secondary analysis on >355,000 UK Biobank participants ≥50 years at baseline. Alzheimer's disease and all-cause dementia are both related to hospital-treated infection. Cardiovascular health modifies association of infection burden with all-cause dementia.</p>
9 Authors
- Hind A. Beydoun
- May A. Beydoun
- Osorio Meirelles
- Lance D. Erickson
- Alyssa A. Gamaldo
- Jordan Weiss
- Lenore J. Launer
- Michele K. Evans
- Alan B. Zonderman
1 Application
| Application ID | Title |
|---|---|
| 77963 | Dissecting racial/ethnic disparities in dementia traits through socio-economic, lifestyle, cardio-metabolic risk and infectious agents, with focus on Helicobacter pylori sero-positivity |
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