| Title: | Associations of inner retinal layers with risk of incident dementia: An individual participant data analysis of four prospective cohort studies |
| Journal: | Alzheimer's & Dementia |
| Published: | 8 Aug 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37551793/ |
| DOI: | https://doi.org/10.1002/alz.13167 |
| URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/alz.13167 |
Publication 10183
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Abstract
INTRODUCTION: Our main objective was to investigate whether retinal neurodegeneration, estimated from lower thickness of inner retinal layers, was associated with incident all-cause dementia and Alzheimer's disease (AD).</p>
METHODS: We performed an individual participant data meta-analysis using unpublished data from four prospective cohort studies with a total of 69,955 participants (n = 1087 cases of incident all-cause dementia; n = 520 cases incident AD; follow-up time median [interquartile range] 11.3 [8.8-11.5] years).</p>
RESULTS: General baseline characteristics of the study population were mean (standard deviation) age, 58.1 (8.8) years; 47% women. After adjustment, lower baseline macular retinal nerve fiber layer thickness was significantly associated with a 10% and 11% higher incidence of all-cause dementia and AD, respectively. Lower baseline macular ganglion cell-inner plexiform layer thickness was not significantly associated with these outcomes.</p>
DISCUSSION: These findings suggest that retinal neurodegeneration precedes the onset of clinical dementia. Retinal imaging tools may be informative biomarkers for the study of the early pathophysiology of dementia.</p>
20 Authors
- Frank C. T. van der Heide
- Anthony Khawaja
- Tos T. J. M. Berendschot
- Thomas J. Littlejohns
- Elżbieta Kuźma
- Robert Luben
- Praveen J. Patel
- Paul J. Foster
- The Maastricht Study Consortium
- Geir Bertelsen
- Therese von Hanno
- Bente Johnsen
- Henrik Schirmer
- Sara C. L. Rebouças
- Leslie Grasset
- Cécile Delcourt
- Catherine Helmer
- Biobank Eye & Vision Consortium
- E3 consortium
- Coen D. A. Stehouwer
1 Application
| Application ID | Title |
|---|---|
| 36741 | Discovering the biological mechanisms underlying glaucoma and neurodegeneration by analysis of genetic and environmental determinants and associations with other systemic traits in the UK Biobank |
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