| Title: | New role of fat-free mass in cancer risk linked with genetic predisposition |
| Journal: | Scientific Reports |
| Published: | 27 Mar 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38538606/ |
| DOI: | https://doi.org/10.1038/s41598-024-54291-7 |
| URL: | https://www.nature.com/articles/s41598-024-54291-7.pdf |
Publication 10031
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Abstract
Cancer risk is associated with the widely debated measure body mass index (BMI). Fat mass and fat-free mass measurements from bioelectrical impedance may further clarify this association. The UK Biobank is a rare resource in which bioelectrical impedance and BMI data was collected on ~ 500,000 individuals. Using this dataset, a comprehensive analysis using regression, principal component and genome-wide genetic association, provided multiple levels of evidence that increasing whole body fat (WBFM) and fat-free mass (WBFFM) are both associated with increased post-menopausal breast cancer risk, and colorectal cancer risk in men. WBFM was inversely associated with prostate cancer. We also identified rs615029[T] and rs1485995[G] as associated in independent analyses with both PMBC (p = 1.56E-17 and 1.78E-11) and WBFFM (p = 2.88E-08 and 8.24E-12), highlighting splice variants of the intriguing long non-coding RNA CUPID1 (LINC01488) as a potential link between PMBC risk and fat-free mass.</p>
11 Authors
- Benjamin H. L. Harris
- Matteo Di Giovannantonio
- Ping Zhang
- David A. Harris
- Simon R. Lord
- Naomi E. Allen
- Tim S. Maughan
- Richard J. Bryant
- Adrian L. Harris
- Gareth L. Bond
- Francesca M. Buffa
1 Application
| Application ID | Title |
|---|---|
| 43313 | Hypoxia, metabolism and their related pathways |
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