| Title: | Perinatal photoperiod associations with bipolar disorder and depression: A systematic literature review and cross-sectional analysis of the UK Biobank database |
| Journal: | Psychiatry Research |
| Published: | 26 Mar 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38581863/ |
| DOI: | https://doi.org/10.1016/j.psychres.2024.115878 |
Publication 10030
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Abstract
Season-of-birth associations with psychiatric disorders point to environmental (co-)aetiological factors such as natural photoperiod that, if clarified, may allow interventions toward prevention. We systematically reviewed the literature concerning season-of-birth and bipolar disorder and depression and explored associations between the perinatal natural photoperiod and these outcomes in a cross-sectional analysis of the UK Biobank database. We used mean daily photoperiod and relative photoperiod range (relative to the mean) in the 3rd trimester and, separately, in the first 3 months post birth as metrics. From review, increased risk of depression with late spring birth is compatible with increased odds of probable single episode-, probable recurrent-, and diagnosed depression (OR 2.85 95 %CI 1.6-5.08, OR 2.20 95 %CI 1.57-3.1, and OR 1.48 95 %CI 1.11-1.97, respectively) with increasing 3rd trimester relative photoperiod range for participants who experienced relatively non-extreme daily photoperiods. Risk of bipolar disorder with winter-spring birth contrasted with no consistent patterns of perinatal photoperiod metric associations with bipolar disorder in the UK Biobank. As natural photoperiod varies by both time-of-year and latitude, perinatal natural photoperiods (and a hypothesized mechanism of action via the circadian timing system and/or serotonergic circuitry associated with the dorsal raphe nucleus) may reconcile inconsistencies in season-of-birth associations. Further studies are warranted.</p>
5 Authors
- Philip Lewis
- John F Gottlieb
- Peter Morfeld
- Martin Hellmich
- Thomas C Erren
1 Application
| Application ID | Title |
|---|---|
| 44219 | Perinatal Light Imprinting Circadian Clocks and Systems (PLICCS) and Associations with Disease in the UK BIOBANK |
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