| Title: | Regular Use of Aspirin and Statins Reduces the Risk of Cancer in Individuals with Systemic Inflammatory Diseases. |
| Journal: | Cancer Research |
| Published: | 27 Mar 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38536116/ |
| DOI: | https://doi.org/10.1158/0008-5472.can-23-2941 |
Publication 10024
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Abstract
Aspirin has shown potential for cancer prevention, but a recent large randomized controlled trial found no evidence for a reduction in cancer risk. Given the anti-inflammatory effects of aspirin, systemic inflammatory diseases (SID), such as osteoporosis, cardiovascular diseases, and metabolic diseases, could potentially modify the aspirin-cancer link. To investigate the impact of aspirin in people with SIDs, we conducted an observational study on a prospective cohort of 478,615 UK Biobank participants. Individuals with at least one of the 41 SIDs displayed a higher cancer risk than those without SIDs. Regular aspirin use showed protective effects exclusively in patients with SID, contrasting an elevated risk among their non-SID counterparts. Nonetheless, aspirin use demonstrated preventative potential only for 9 of 21 SID-associated cancer subtypes. Cholesterol emerged as another key mediator linking SIDs to cancer risk. Notably, regular statin use displayed protective properties in patients with SID but not in their non-SID counterparts. Concurrent use of aspirin and statins exhibited a stronger protective association in patients with SID, covering 14 common cancer subtypes. In summary, patients with SIDs may represent a population particularly responsive to regular aspirin and statin use. Promoting either combined or individual use of these medications within the context of SIDs could offer a promising chemoprevention strategy.</p>
SIGNIFICANCE: Individuals with systemic inflammatory diseases derive chemoprotective benefits from aspirin and statins, providing a precision cancer prevention approach to address the personal and public challenges posed by cancer.</p>
12 Authors
- Jia-Run Lin
- Duan-Duan Han
- Wei Wei
- Qin Zeng
- Zi-Xuan Rong
- Xue Bai
- Yan-Pei Zhang
- Jian Wang
- Xiao-Ting Cai
- Xu-Guang Rao
- Si-Cong Ma
- Zhong-Yi Dong
Enabling scientific discoveries that improve human health