| Title: | Associations between polygenic liability to psychopathology and non-suicidal versus suicidal self-injury |
| Journal: | American Journal of Medical Genetics Part B Neuropsychiatric Genetics |
| Published: | 29 Mar 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38551161/ |
| DOI: | https://doi.org/10.1002/ajmg.b.32982 |
| URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ajmg.b.32982 |
Publication 10010
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Abstract
Little is known about how non-suicidal and suicidal self-injury are differentially genetically related to psychopathology and related measures. This research was conducted using the UK Biobank Resource, in participants of European ancestry (N = 2320 non-suicidal self-injury [NSSI] only; N = 2648 suicide attempt; 69.18% female). We compared polygenic scores (PGS) for psychopathology and other relevant measures within self-injuring individuals. Logistic regressions and likelihood ratio tests (LRT) were used to identify PGS that were differentially associated with these outcomes. In a multivariable model, PGS for anorexia nervosa (odds ratio [OR] = 1.07; 95% confidence intervals [CI] 1.01; 1.15) and suicidal behavior (OR = 1.06; 95% CI 1.00; 1.12) both differentiated between NSSI and suicide attempt, while the PGS for other phenotypes did not. The LRT between the multivariable and base models was significant (Chi square = 11.38, df = 2, p = 0.003), and the multivariable model explained a larger proportion of variance (Nagelkerke's pseudo-R2 = 0.028 vs. 0.025). While NSSI and suicidal behavior are similarly genetically related to a range of mental health and related outcomes, genetic liability to anorexia nervosa and suicidal behavior is higher among those reporting a suicide attempt than those reporting NSSI-only. Further elucidation of these distinctions is necessary, which will require a nuanced assessment of suicidal versus non-suicidal self-injury in large samples.</p>
5 Authors
- Alexis C. Edwards
- Madhurbain Singh
- Roseann E. Peterson
- Bradley T. Webb
- Amanda E. Gentry
1 Application
| Application ID | Title |
|---|---|
| 30782 | On the genetic and environmental intersection of mental and physical health |
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