| Title: | Associations of dietary patterns with brain health from behavioral, neuroimaging, biochemical and genetic analyses |
| Journal: | Nature Mental Health |
| Published: | 1 Apr 2024 |
| DOI: | https://doi.org/10.1038/s44220-024-00226-0 |
| URL: | https://www.nature.com/articles/s44220-024-00226-0.pdf |
Publication 10000
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Abstract
Food preferences significantly influence dietary choices, yet understanding natural dietary patterns in populations remains limited. Here we identifiy four dietary subtypes by applying data-driven approaches to food-liking data from 181,990 UK Biobank participants: 'starch-free or reduced-starch' (subtype 1), 'vegetarian' (subtype 2), 'high protein and low fiber' (subtype 3) and 'balanced' (subtype 4). These subtypes varied in diverse brain health domains. The individuals with a balanced diet demonstrated better mental health and superior cognitive functions relative to other three subtypes. Compared with subtype 4, subtype 3 displayed lower gray matter volumes in regions such as the postcentral gyrus, while subtype 2 showed higher volumes in thalamus and precuneus. Genome-wide association analyses identified 16 genes different between subtype 3 and subtype 4, enriched in biological processes related to mental health and cognition. These findings provide new insights into naturally developed dietary patterns, highlighting the importance of a balanced diet for brain health.</p>
10 Authors
- Ruohan Zhang
- Bei Zhang
- Chun Shen
- Barbara J. Sahakian
- Zeyu Li
- Wei Zhang
- Yujie Zhao
- Yuzhu Li
- Jianfeng Feng
- Wei Cheng
1 Application
| Application ID | Title |
|---|---|
| 19542 | Identifying multi-level biomarkers and disease mechanisms for major mental disorders |
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