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Using Mendelian randomization, our study suggests that haemoglobin (HGB) is the key red blood cell trait causing venous thromboembolism (VTE). Given men have higher HGB than women, this finding may help explain the sexual disparity in VTE rates. The benefits of therapies and other factors that raise HGB need to be weighed against their risks.
Evaluation of the causal relation between hematocrit, hemoglobin, HbA1c, testosterone and cardiovascular outcomes in the UK Biobank using Mendelian randomization analysis
The aims of this study are to examine the causal effect of testosterone, HbA1c, hemoglobin and hematocrit on CVD risk factors, prevalent CVD and CVD deaths using Mendelian randomization analysis, with the relevant genetic variants as instruments in the UK Biobank. The proposed research will help investigate how these potential targets of intervention influence population health using Mendelian randomization design which is less susceptible to confounding than observational studies. The results will provide additional insights concerning the drivers of cardiovascular disease, with corresponding implications for public health policies and the development of interventions. We compare cardiovascular events and risk factors according to levels of genetically determined hematocrit, hemoglobin, HbA1c and testosterone. 500,000 participants (full cohort) for the analysis involving hematocrit, hemoglobin, HbA1c and genetic data. We will restrict the analysis involving testosterone and relevant genetic data among men.