Some studies have shown that persons with chronic widespread pain experience premature mortality, although data is equivocal. Attempts to investigate the mediators of such a relationship have focused on low levels of physical activity, and other lifestyle factors such as smoking and poor diet. Here, we used data from UK Biobank to determine whether such a relationship exists, estimate its magnitude and establish what factors mediate any relationship.
Approximately 0.5 million people ages 40-69yrs were followed from study recruitment (2006-2010) by linking to national death records up to mid-2015. Mortality among persons reporting pain all over the body for at least three months was compared with persons without chronic pain. 7130 participants reported chronic widespread pain at recruitment, and these individuals were more than twice as likely to die during followup, compared to persons with no chronic pain, in particular due to cancer, cardiovascular disease, respiratory disease, or from other disease-related causes. However, the excess risk was considerably reduced when adjusting for low levels of physical activity, high body mass index, poor quality diet and smoking.
Evidence is now clear that persons with chronic widespread pain experience excess mortality. Data from UK Biobank considerably reduces the uncertainty around the magnitude of excess risk and are consistent with the excess being explained by adverse lifestyle factors. These factors should be targeted in the management of such patients.
Epidemiology of chronic pain
This project will investigate the epidemiology of chronic pain. It will determine:
* how common pain is at individual sites throughout the body as well as `widespread body pain`
*the factors associated with the reporting of pain including demographic (age, sex, socioeconomic status), lifestyle factors (smoking , alcohol, physical activity)
*other health related factors reported with pain (e.g. fatigue and mood disorders)
*whether persons who report pain also report markers of poor cardiovascular (heart) and respiratory (lung) health and whether their lifestyle puts them at an increased risk of cancer.
*the relationship between reporting of pain and history of falls and fractures.
The project meets Biobank's purpose by researching common and disabling symptoms in the population with a view to further understanding their aetiology. Such knowledge will help to inform the design of future trials to optimise management.
This application requires only data on the full cohort. project It requires linkage to cancer incidence and mortality data (as and when it becomes available), and requires baseline data on lifestyle and psychosocial factors, medical conditions, bone densitometry and blood pressure;
|Lead investigator:||Professor Gary Macfarlane|
|Lead institution:||University of Aberdeen|
4 related Returns
|Return ID||App ID||Description||Archive Date|
|421||1144||Chronic widespread bodily pain is increased among individuals with history of fracture: findings from UK Biobank||9 May 2017|
|2764||1144||Is alcohol consumption related to likelihood of reporting chronic widespread pain in people with stable consumption? Results from UK biobank||3 Nov 2020|
|1541||1144||Self-Reported Facial Pain in UK Biobank Study: Prevalence and Associated Factors||10 Aug 2018|
|3417||1144||The epidemiology of regular opioid use and its association with mortality: Prospective cohort study of 466 486 UK biobank participants||18 May 2021|
|2767||Persons with chronic widespread pain experience excess mortality: longitudinal results from UK Biobank and meta-analysis||Macfarlane GJ et al.||2017||Ann Rheum Dis|