| Title: | Neuroanatomical and prognostic associations of depression in Parkinson's disease |
| Journal: | Journal of Neurology Neurosurgery & Psychiatry |
| Published: | 3 Apr 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38569876/ |
| DOI: | https://doi.org/10.1136/jnnp-2023-333007 |
| URL: | https://jnnp.bmj.com/content/jnnp/early/2024/04/03/jnnp-2023-333007.full.pdf |
Publication 9972
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
BACKGROUND: Depression is reported as a risk factor, prodromal feature and late consequence of Parkinson's disease (PD). We aimed to evaluate the timing, neuroanatomy and prognostic implications of depression in PD.</p>
METHODS: We used data from 434 023 participants from UK Biobank with 14.1 years of follow-up. Multivariable regression models established associations of depression with incident PD and regional brain volumes. Cox proportional hazards models assessed prognostic associations of depression in PD with incident dementia and all-cause mortality.</p>
RESULTS: Of 2632 individuals with incident PD, 539 (20.5%) were diagnosed with depression at some point. Depression was associated with an increased risk of subsequent PD (risk ratio 1.53, 95% CI 1.37 to 1.72). Among incident PD cases, depression prevalence rose progressively from 10 years pre-PD diagnosis (OR 2.10, 95% CI 1.57 to 2.83) to 10 years postdiagnosis (OR 3.51, 95% CI 1.33 to 9.22). Depression severity in PD was associated with reduced grey matter volume in structures including the thalamus and amygdala. Depression prior to PD diagnosis increased risk of dementia (HR 1.47, 95% CI 1.05 to 2.07) and mortality (HR 1.30, 95% CI 1.07 to 1.58).</p>
CONCLUSIONS: This large-scale prospective study demonstrated that depression prevalence increases from 10 years before PD diagnosis and is a marker of cortical and subcortical volume loss. Depression before PD diagnosis signals a worse prognosis in terms of dementia and mortality. This has clinical implications in stratifying people with poorer cognitive and prognostic trajectory in PD.</p>
6 Authors
- James B Badenoch
- Alvar Paris
- Benjamin Meir Jacobs
- Alastair J Noyce
- Charles R Marshall
- Sheena Waters
1 Application
| Application ID | Title |
|---|---|
| 78867 | Genetic and environmental determinants of brain function in health and disease |
Enabling scientific discoveries that improve human health