| Title: | Association of Ultraprocessed Food Consumption with Risk of Cardiovascular Disease Among Individuals with Type 2 Diabetes: Findings from the UK Biobank |
| Journal: | Molecular Nutrition & Food Research |
| Published: | 19 Apr 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38639304/ |
| DOI: | https://doi.org/10.1002/mnfr.202300314 |
Publication 9856
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Abstract
SCOPE: Among patients with diabetes, who have modified nutritional behavior and a higher risk of cardiovascular disease (CVD), the influence of ultraprocessed foods (UPFs) on CVD remains unknown. The study aims to evaluate the association between UPF intake and the risk of CVD among individuals with type 2 diabetes (T2D) and further examine the potential biological pathways linking the association.</p>
METHODS AND RESULTS: This study includes 5405 participants with T2D who provided at least one 24-h dietary recall from the UK Biobank study. In the fully adjusted models, a 10% increase in the proportion of UPFs is associated with higher hazards of overall CVD (hazard ratio [HR]: 1.10; 95% confidence interval [CI]: 1.04, 1.15), coronary heart disease (HR: 1.10; 95% CI: 1.04, 1.16), heart failure (HR: 1.14; 95% CI: 1.05, 1.25), but not stroke (HR: 1.01; 95% CI: 0.90, 1.12). Cystatin C, high-density lipoprotein cholesterol (HDL-C), apolipoprotein A, C-reactive protein, and body mass index collectively explain 26.9% (12.8%, 48.5%) of the association between UPF intake and the risk of overall CVD.</p>
CONCLUSION: Higher UPF intakes are associated with increased hazards of CVD among individuals with T2D, and the association is partly mediated through worsening biomarkers of renal function, lipid metabolism, inflammation, and body weight.</p>
10 Authors
- Yue Li
- Yuwei Lai
- Tingting Geng
- Peng-Fei Xia
- Jun-Xiang Chen
- Zhou-Zheng Tu
- Kun Yang
- Yun-Fei Liao
- Gang Liu
- An Pan
1 Application
| Application ID | Title |
|---|---|
| 68307 | Environmental and genetic determinants of morbidity and mortality among adults with cardiometabolic disorders |
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