| Title: | Associations between handgrip strength and skeletal muscle mass with all-cause mortality and cardiovascular mortality in people with type 2 diabetes: A prospective cohort study of the UK Biobank |
| Journal: | Journal of Diabetes |
| Published: | 22 Aug 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37608605/ |
| DOI: | https://doi.org/10.1111/1753-0407.13464 |
| URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1753-0407.13464 |
Publication 9720
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Abstract
AIMS: To explore the associations between handgrip strength (HGS) and skeletal muscle mass (SMM) with all-cause and cardiovascular disease (CVD) mortality risk in type 2 diabetes (T2DM) patients.</p>
MATERIALS AND METHODS: Data were obtained from the UK Biobank. Baseline survey was conducted between 2006 and 2010, and followed up for a median of 12.52 years. HGS was measured using dynamometer, and SMM was measured using bioelectrical impedance method. Mortality was available via links to the National Health Service Information Centre. Sex-specific analyses were conducted.</p>
RESULTS: A total of 13 392 T2DM participants were included, with a mean age of 60.39 years and 52.35% men. During the follow-up, there were 3006 (22.45%) deaths, including 746 (5.57%) CVD deaths. The risk for all-cause mortality and CVD mortality among both men and women increased progressively with decreasing HGS quartiles (p trend <.05). A 1 SD decrease in HGS was found to both increase the all-cause risk (HR: 1.31 [95% CI: 1.24-1.38]) and CVD mortality risk (HR: 1.35 [95% CI: 1.22-1.50]) for men, and all-cause risk (HR: 1.26 [95% CI: 1.11-1.42]) and CVD mortality risk (HR: 1.43 [95% CI: 1.09-1.89]) for women. There was no statistically significant trend association between SMM/height2 and mortality risk, and the restricted cubic regression splines indicated that SMM/height2 showed a U-shaped nonlinear relationship (pnonlinear <.05).</p>
CONCLUSIONS: Grip strength displayed a linear downward trend with mortality risk among T2DM patients, whereas muscle mass showed a U-shaped relationship. Low grip strength seemed to be a better predictor for mortality compared to low muscle mass.</p>
7 Authors
- Lingqi Wei
- Jingjing Zeng
- Menglin Fan
- Bo Chen
- Xiaying Li
- Ying Li
- Shaoyong Xu
1 Application
| Application ID | Title |
|---|---|
| 92014 | Associations of Combined Genetic and Lifestyle Risks With Incident Cardiovascular Disease and Cancers |
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