| Title: | Genetic factors, adherence to healthy lifestyle behaviors, and risk of bladder cancer |
| Journal: | BMC Cancer |
| Published: | 12 Oct 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37828430/ |
| DOI: | https://doi.org/10.1186/s12885-023-11455-4 |
| URL: | https://bmccancer.biomedcentral.com/counter/pdf/10.1186/s12885-023-11455-4 |
| Citations: | 3 (3 in last 2 years) as of 8 Aug 2024 |
Publication 9388
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Abstract
BackgroundGenetic and lifestyle factors both contribute to the pathogenesis of bladder cancer, but the extent to which the increased genetic risk can be mitigated by adhering to a healthy lifestyle remains unclear. We aimed to investigate the association of combined lifestyle factors with bladder cancer risk within genetic risk groups.MethodsWe conducted a prospective study of 375 998 unrelated participants of European ancestry with genotype and lifestyle data and free of cancer from the UK biobank. We generated a polygenic risk score (PRS) using 16 single nucleotide polymorphisms and a healthy lifestyle score based on body weight, smoking status, physical activity, and diet. Cox models were fitted to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) of genetic and lifestyle factors on bladder cancer.ResultsDuring a median follow-up of 11.8 years, 880 participants developed bladder cancer. Compared with those with low PRS, participants with intermediate and high PRS had a higher risk of bladder cancer (HR 1.29, 95% CI 1.07-1.56; HR 1.63, 95% CI 1.32-2.02, respectively). An optimal lifestyle was associated with an approximately 50% lower risk of bladder cancer than a poor lifestyle across all genetic strata. Participants with a high genetic risk and a poor lifestyle had 3.6-fold elevated risk of bladder cancer compared with those with a low genetic risk and an optimal lifestyle (HR 3.63, 95% CI 2.23 -5.91).ConclusionsAdhering to a healthy lifestyle could substantially reduce the bladder cancer risk across all genetic strata, even for high-genetic risk individuals. For all populations, adopting an intermediate lifestyle is more beneficial than a poor one, and adhering to an optimal lifestyle is the ideal effective strategy for bladder cancer prevention.</p>
12 Authors
- Qiangsheng He
- Siqing Wu
- Ying Zhou
- Yuchen Liu
- Bin Xia
- Wenjing Li
- Jinyu Zhao
- Ningning Mi
- Peng Xie
- Xiwen Qin
- Jinqiu Yuan
- Yihang Pan
1 Application
| Application ID | Title |
|---|---|
| 51671 | Metabolism syndrome and risk of cancer |
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