| Title: | Looking for Sunshine: Genetic Predisposition to Sun Seeking in 265,000 Individuals of European Ancestry |
| Journal: | Journal of Investigative Dermatology |
| Published: | 10 Sep 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/32920024/ |
| DOI: | https://doi.org/10.1016/j.jid.2020.08.014 |
| URL: | http://www.jidonline.org/article/S0022202X20320492/pdf |
Publication 9228
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Abstract
Despite growing public awareness of the adverse consequences of excessive sun exposure, modifying sun-seeking behavior is challenging because it appears to be driven by addictive mechanisms. This can have effects on health because sun exposure, although beneficial, when prolonged and repeated shows a causal relationship with skin cancer risk. Using data from 2,500 United Kingdom twins, we observed sun seeking to be significantly heritable (h2 ≥ 58%). In a GWAS meta-analysis of sun-seeking behavior in 261,915 subjects of European ancestry, we identified five GWAS-significant loci previously associated with addiction, behavioral and personality traits, cognitive function, and educational attainment and enriched for CNS gene expression: MIR2113 (P = 2.08 × 10-11), FAM76B/MTMR2/CEP57 (P = 3.70 × 10-9), CADM2 (P = 9.36 × 10-9), TMEM182 (P = 1.64 × 10-8), and PLCL1/LINC01923/SATB2 (P = 3.93 × 10-8). These findings imply that the behavior concerning UV exposure is complicated by a genetic predisposition shared with neuropsychological traits. This should be taken into consideration when designing awareness campaigns and may help improve people's attitudes toward sun exposure.</p>
10 Authors
- Marianna Sanna
- Xin Li
- Alessia Visconti
- Maxim B Freidin
- Chiara Sacco
- Simone Ribero
- Pirro Hysi
- Veronique Bataille
- Jiali Han
- Mario Falchi
1 Application
| Application ID | Title |
|---|---|
| 12052 | Study of genetic factors altering susceptibility to quantitative traits underlying skin cancer |
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