| Title: | Minimal phenotyping yields genome-wide association signals of low specificity for major depression |
| Journal: | Nature Genetics |
| Published: | 30 Mar 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/32231276/ |
| DOI: | https://doi.org/10.1038/s41588-020-0594-5 |
| URL: | http://www.scopus.com/inward/record.url?scp=85083042151&partnerID=8YFLogxK |
| Citations: | 246 (100 in last 2 years) as of 8 Aug 2024 |
Publication 9107
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Abstract
Minimal phenotyping refers to the reliance on the use of a small number of self-reported items for disease case identification, increasingly used in genome-wide association studies (GWAS). Here we report differences in genetic architecture between depression defined by minimal phenotyping and strictly defined major depressive disorder (MDD): the former has a lower genotype-derived heritability that cannot be explained by inclusion of milder cases and a higher proportion of the genome contributing to this shared genetic liability with other conditions than for strictly defined MDD. GWAS based on minimal phenotyping definitions preferentially identifies loci that are not specific to MDD, and, although it generates highly predictive polygenic risk scores, the predictive power can be explained entirely by large sample sizes rather than by specificity for MDD. Our results show that reliance on results from minimal phenotyping may bias views of the genetic architecture of MDD and impede the ability to identify pathways specific to MDD.</p>
16 Keywords
- Adult
- Aged
- Bipolar Disorder
- Depressive Disorder, Major
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Genotype
- Humans
- Male
- Middle Aged
- Multifactorial Inheritance
- Phenotype
- Polymorphism, Single Nucleotide
- Risk Factors
- Sensitivity and Specificity
32 Authors
- Na Cai
- Joana A. Revez
- Mark J. Adams
- Till F. M. Andlauer
- Gerome Breen
- Enda M. Byrne
- Toni-Kim Clarke
- Andreas J. Forstner
- Hans J. Grabe
- Steven P. Hamilton
- Douglas F. Levinson
- Cathryn M. Lewis
- Glyn Lewis
- Nicholas G. Martin
- Yuri Milaneschi
- Ole Mors
- Bertram Müller-Myhsok
- Brenda W. J. H. Penninx
- Roy H. Perlis
- Giorgio Pistis
- James B. Potash
- Martin Preisig
- Jianxin Shi
- Jordan W. Smoller
- Fabien Streit
- Henning Tiemeier
- Rudolf Uher
- Sandra Van der Auwera
- Alexander Viktorin
- Myrna M. Weissman
- Kenneth S. Kendler
- Jonathan Flint
1 Application
| Application ID | Title |
|---|---|
| 28709 | Clinical heterogeneity in depression |
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