| Title: | Establishing the variation of blood metrics within UK Biobank to inform cell therapy manufacturing processes |
| Journal: | Regenerative Medicine |
| Published: | 13 Nov 2019 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/31718498/ |
| DOI: | https://doi.org/10.2217/rme-2018-0168 |
| URL: | https://figshare.com/articles/journal_contribution/Establishing_the_variation_of_blood_metrics_within_UK_Biobank_to_inform_cell_therapy_manufacturing_processes/9938966/1/files/17890967.pdf |
Publication 9049
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Abstract
Aim: Understanding blood component variation as a function of healthy population metrics is necessary to inform biomanufacturing process design. Methods: UK Biobank metrics were examined for variation in white blood cell count as an analog to potential manufacturing starting material input. Results: White blood cell count variation of four orders of magnitude (6.65 × 109 cells/l) was found. Variation increased with age, increased with weight up to 80 kg then decreased. Health state showed a greater absolute number of participants with elevated count. Female range was greater than male. Cell count/distributions were different between centers. Conclusion: This variation and range of process input signals a requirement for new strategies for manufacturing process design and control.</p>
3 Authors
- Jamie Thurman-Newell
- Jon Petzing
- David J Williams
1 Application
| Application ID | Title |
|---|---|
| 4047 | Quantification of Variation in Blood |
Enabling scientific discoveries that improve human health