| Title: | Particulate matter exposure may increase the risk of irritable bowel syndrome: a large-scale prospective study based on the UK Biobank |
| Journal: | Environmental Science Nano |
| Published: | 14 Mar 2024 |
| DOI: | https://doi.org/10.1039/d3en00650f |
Publication 9031
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Abstract
Long-term exposure to PM 10 and PM 2.5 increases the risk of IBS, especially PM 2.5 . </p>
Background : irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders and considerably contributes to the global disease burden. Ambient air pollution, especially particulate matter (PM), could be a risk factor for IBS. However, limited evidence has linked PM exposure to IBS. Methods : we conducted a large-scale prospective cohort study based on the UK Biobank. The annual average concentrations of PM 10 , PM 2.5-10 , and PM 2.5 were obtained from the ESCAPE study using the land-use regression (LUR) model. The Cox proportional hazard model was used to calculate hazard ratios (HRs) at 95% confidence intervals (95% CIs) of PM with IBS incidence. We further explored the exposure-response relationship curve and performed several stratified analyses based on sex, age, BMI, and other factors. Results : during a follow-up period of 13.7 years, 5796 individuals diagnosed with IBS were identified. We estimated that the HRs of IBS associated with a 10 μg m −3 increase in PM 10 , PM 2.5-10 , and PM 2.5 were 1.14 (95% CI: 1.01, 1.29), 1.16 (95% CI: 0.90, 1.50), and 1.33 (95% CI: 1.04, 1.68), respectively. We estimated an almost linear exposure-response relationship between PM 10 and PM 2.5 exposure and IBS. Individuals under 60 years old were more vulnerable to PM exposure. Conclusions : our study provided robust evidence on the association between long-term PM 10 and PM 2.5 exposure and IBS; and the impact of PM 2.5 was higher than that of PM 10 . We further suggest restricting the ambient PM standards to reduce the impact of PM exposure on IBS. </p>
8 Authors
- Yan Ran
- Jian Lei
- Laifu Li
- Lianli Wang
- Yating Sun
- Lin Mei
- Fangchen Ye
- Fei Dai
1 Application
| Application ID | Title |
|---|---|
| 99732 | Identifying the risk factors of digestive diseases and the potential relationships with other diseases |
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