| Title: | NHS Health Check attendance is associated with reduced multiorgan disease risk: a matched cohort study in the UK Biobank |
| Journal: | BMC Medicine |
| Published: | 23 Jan 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38254067/ |
| DOI: | https://doi.org/10.1186/s12916-023-03187-w |
| URL: | https://bmcmedicine.biomedcentral.com/counter/pdf/10.1186/s12916-023-03187-w |
| Citations: | 2 (2 in last 2 years) as of 8 Aug 2024 |
Publication 8907
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Abstract
BackgroundThe NHS Health Check is a preventive programme in the UK designed to screen for cardiovascular risk and to aid in primary disease prevention. Despite its widespread implementation, the effectiveness of the NHS Health Check for longer-term disease prevention is unclear. In this study, we measured the rate of new diagnoses in UK Biobank participants who underwent the NHS Health Check compared with those who did not.MethodsWithin the UK Biobank prospective study, 48,602 NHS Health Check recipients were identified from linked primary care records. These participants were then covariate-matched on an extensive range of socio-demographic, lifestyle, and medical factors with 48,602 participants without record of the check. Follow-up diagnoses were ascertained from health records over an average of 9 years (SD 2 years) including hypertension, diabetes, hypercholesterolaemia, stroke, dementia, myocardial infarction, atrial fibrillation, heart failure, fatty liver disease, alcoholic liver disease, liver cirrhosis, liver failure, acute kidney injury, chronic kidney disease (stage 3 +), cardiovascular mortality, and all-cause mortality. Time-varying survival modelling was used to compare adjusted outcome rates between the groups.ResultsIn the immediate 2 years after the NHS Health Check, higher diagnosis rates were observed for hypertension, high cholesterol, and chronic kidney disease among health check recipients compared to their matched counterparts. However, in the longer term, NHS Health Check recipients had significantly lower risk across all multiorgan disease outcomes and reduced rates of cardiovascular and all-cause mortality.ConclusionsThe NHS Health Check is linked to reduced incidence of disease across multiple organ systems, which may be attributed to risk modification through earlier detection and treatment of key risk factors such as hypertension and high cholesterol. This work adds important evidence to the growing body of research supporting the effectiveness of preventative interventions in reducing longer-term multimorbidity.</p>
11 Authors
- Celeste McCracken
- Zahra Raisi-Estabragh
- Liliana Szabo
- John Robson
- Betty Raman
- Anya Topiwala
- Adriana Roca-Fernández
- Masud Husain
- Steffen E. Petersen
- Stefan Neubauer
- Thomas E. Nichols
1 Application
| Application ID | Title |
|---|---|
| 59867 | Assessment of the heart-brain-liver-axis in the UK Biobank Imaging study |
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