| Title: | Genetic characteristics involved in COVID-19 severity. The CARGENCORS case-control study and meta-analysis |
| Journal: | Journal of Medical Virology |
| Published: | 31 Jan 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38293834/ |
| DOI: | https://doi.org/10.1002/jmv.29404 |
| URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/jmv.29404 |
Publication 8840
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Abstract
Pre-existing coronary artery disease (CAD), and thrombotic, inflammatory, or virus infectivity response phenomena have been associated with COVID-19 disease severity. However, the association of candidate single nucleotide variants (SNVs) related to mechanisms of COVID-19 complications has been seldom analysed. Our aim was to test and validate the effect of candidate SNVs on COVID-19 severity. CARGENCORS (CARdiovascular GENetic risk score for Risk Stratification of patients positive for SARS-CoV-2 [COVID-19] virus) is an age- and sex-matched case-control study with 818 COVID-19 cases hospitalized with hypoxemia, and 1636 controls with COVID-19 treated at home. The association between severity and SNVs related to CAD (n = 32), inflammation (n = 19), thrombosis (n = 14), virus infectivity (n = 11), and two published to be related to COVID-19 severity was tested with adjusted logistic regression models. Two external independent cohorts were used for meta-analysis (SCOURGE and UK Biobank). After adjustment for potential confounders, 14 new SNVs were associated with COVID-19 severity in the CARGENCORS Study. These SNVs were related to CAD (n = 10), thrombosis (n = 2), and inflammation (n = 2). We also confirmed eight SNVs previously related to severe COVID-19 and virus infectivity. The meta-analysis showed five SNVs associated with severe COVID-19 in adjusted analyses (rs11385942, rs1561198, rs6632704, rs6629110, and rs12329760). We identified 14 novel SNVs and confirmed eight previously related to COVID-19 severity in the CARGENCORS data. In the meta-analysis, five SNVs were significantly associated to COVID-19 severity, one of them previously related to CAD.</p>
21 Authors
- Anna Camps-Vilaró
- Mel·lina Pinsach-Abuin
- Irene R. Degano
- Rafel Ramos
- Ruth Martí-Lluch
- Roberto Elosua
- Isaac Subirana
- Clàudia Solà-Richarte
- Marta Puigmulé
- Alexandra Pérez
- Ingrid Vilaró
- Raquel Cruz
- Silvia Diz-de Almeida
- Xavier Nogues
- Joan R. Masclans
- Roberto Güerri-Fernández
- Judith Marin
- Helena Tizon-Marcos
- Beatriz Vaquerizo
- Ramon Brugada
- Jaume Marrugat
1 Application
| Application ID | Title |
|---|---|
| 84905 | CARdiovascular GENetic risk score in patients positive for SARS-CoV-2 infection Risk Stratification (CARGENCORS): validation of the significant single nucleotide polymorphisms. |
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