| Title: | Joint Exposure to Multiple Air Pollutants, Genetic Susceptibility, and Incident Dementia: A Prospective Analysis in the UK Biobank Cohort |
| Journal: | International Journal of Public Health |
| Published: | 15 Feb 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38426188/ |
| DOI: | https://doi.org/10.3389/ijph.2024.1606868 |
| URL: | https://www.ssph-journal.org/articles/10.3389/ijph.2024.1606868/pdf |
Publication 8733
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Abstract
Objectives: This study aimed to evaluate the joint effects of multiple air pollutants including PM2.5, PM10, NO2, and NOx with dementia and examined the modifying effects of genetic susceptibility. Methods: This study included 220,963 UK Biobank participants without dementia at baseline. Weighted air pollution score reflecting the joint exposure to multiple air pollutants were constructed by cross-validation analyses, and inverse-variance weighted meta-analyses were performed to create a pooled effect. The modifying effect of genetic susceptibility on air pollution score was assessed by genetic risk score and APOE ε4 genotype. Results: The HR (95% CI) of dementia for per interquartile range increase of air pollution score was 1.13 (1.07∼1.18). Compared with the lowest quartile (Q1) of air pollution score, the HR (95% CI) of Q4 was 1.26 (1.13∼1.40) (P trend = 2.17 × 10-5). Participants with high air pollution score and high genetic susceptibility had higher risk of dementia compared to those with low air pollution score and low genetic susceptibility. Conclusion: Our study provides evidence that joint exposure to multiple air pollutants substantially increases the risk of dementia, especially among individuals with high genetic susceptibility.</p>
9 Authors
- Shuo Zhang
- Hongyan Cao
- Keying Chen
- Tongyu Gao
- Huashuo Zhao
- Chu Zheng
- Ting Wang
- Ping Zeng
- Ke Wang
1 Application
| Application ID | Title |
|---|---|
| 88159 | Fine-mapping, genetic correlation and genetic risk prediction for complex traits in different populations |
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