| Title: | GWAS Identifies Risk Locus for Erectile Dysfunction and Implicates Hypothalamic Neurobiology and Diabetes in Etiology |
| Journal: | American Journal of Human Genetics |
| Published: | 21 Dec 2018 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/30583798/ |
| DOI: | https://doi.org/10.1016/j.ajhg.2018.11.004 |
| URL: | http://www.cell.com/article/S0002929718304075/pdf |
Publication 8678
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Abstract
Erectile dysfunction (ED) is a common condition affecting more than 20% of men over 60 years, yet little is known about its genetic architecture. We performed a genome-wide association study of ED in 6,175 case subjects among 223,805 European men and identified one locus at 6q16.3 (lead variant rs57989773, OR 1.20 per C-allele; p = 5.71 × 10-14), located between MCHR2 and SIM1. In silico analysis suggests SIM1 to confer ED risk through hypothalamic dysregulation. Mendelian randomization provides evidence that genetic risk of type 2 diabetes mellitus is a cause of ED (OR 1.11 per 1-log unit higher risk of type 2 diabetes). These findings provide insights into the biological underpinnings and the causes of ED and may help prioritize the development of future therapies for this common disorder.</p>
22 Authors
- Jonas Bovijn
- Leigh Jackson
- Jenny Censin
- Chia-Yen Chen
- Triin Laisk
- Samantha Laber
- Teresa Ferreira
- Sara L. Pulit
- Craig A. Glastonbury
- Jordan W. Smoller
- Jamie W. Harrison
- Katherine S. Ruth
- Robin N. Beaumont
- Samuel E. Jones
- Jessica Tyrrell
- Andrew R. Wood
- Michael N. Weedon
- Reedik Mägi
- Benjamin Neale
- Cecilia M. Lindgren
- Anna Murray
- Michael V. Holmes
1 Application
| Application ID | Title |
|---|---|
| 11867 | Dissection of the Genetic Susceptibility of Obesity Traits and their Comorbidities |
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