| Title: | Lifetime and 10-year cardiovascular risk prediction in individuals with type 1 diabetes: The LIFE-T1D model |
| Journal: | Diabetes Obesity and Metabolism |
| Published: | 8 Mar 2024 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38456579/ |
| DOI: | https://doi.org/10.1111/dom.15531 |
| URL: | https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/dom.15531 |
| Citations: | 1 (1 in last 2 years) as of 8 Aug 2024 |
Publication 8536
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Abstract
AIMS: To develop and externally validate the LIFE-T1D model for the estimation of lifetime and 10-year risk of cardiovascular disease (CVD) in individuals with type 1 diabetes.</p>
MATERIALS AND METHODS: A sex-specific competing risk-adjusted Cox proportional hazards model was derived in individuals with type 1 diabetes without prior CVD from the Swedish National Diabetes Register (NDR), using age as the time axis. Predictors included age at diabetes onset, smoking status, body mass index, systolic blood pressure, glycated haemoglobin level, estimated glomerular filtration rate, non-high-density lipoprotein cholesterol, albuminuria and retinopathy. The model was externally validated in the Danish Funen Diabetes Database (FDDB) and the UK Biobank.</p>
RESULTS: During a median follow-up of 11.8 years (interquartile interval 6.1-17.1 years), 4608 CVD events and 1316 non-CVD deaths were observed in the NDR (n = 39 756). The internal validation c-statistic was 0.85 (95% confidence interval [CI] 0.84-0.85) and the external validation c-statistics were 0.77 (95% CI 0.74-0.81) for the FDDB (n = 2709) and 0.73 (95% CI 0.70-0.77) for the UK Biobank (n = 1022). Predicted risks were consistent with the observed incidence in the derivation and both validation cohorts.</p>
CONCLUSIONS: The LIFE-T1D model can estimate lifetime risk of CVD and CVD-free life expectancy in individuals with type 1 diabetes without previous CVD. This model can facilitate individualized CVD prevention among individuals with type 1 diabetes. Validation in additional cohorts will improve future clinical implementation.</p>
20 Keywords
- Adult
- Age of Onset
- Body Mass Index
- Cardiovascular Diseases
- Denmark
- Diabetes Mellitus, Type 1
- Diabetic Angiopathies
- Female
- Follow-Up Studies
- Glycated Hemoglobin
- Heart Disease Risk Factors
- Humans
- Male
- Middle Aged
- Proportional Hazards Models
- Registries
- Risk Assessment
- Risk Factors
- Sweden
- United Kingdom
17 Authors
- Marga A. G. Helmink
- Steven H. J. Hageman
- Björn Eliasson
- Naveed Sattar
- Frank L. J. Visseren
- Jannick A. N. Dorresteijn
- Katie Harris
- Sanne A. E. Peters
- Mark Woodward
- Péter Szentkúti
- Kurt Højlund
- Jan Erik Henriksen
- Henrik Toft Sørensen
- Erik H. Serné
- Thomas T. van Sloten
- Reimar W. Thomsen
- Jan Westerink
1 Application
| Application ID | Title |
|---|---|
| 74018 | Sex differences in the determinants and outcomes of multimorbidity clusters and their constituent conditions in the UK Biobank Study |
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