| Title: | Genome-wide association study for risk taking propensity indicates shared pathways with body mass index |
| Journal: | Communications Biology |
| Published: | 3 May 2018 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/30271922/ |
| DOI: | https://doi.org/10.1038/s42003-018-0042-6 |
| URL: | https://www.nature.com/articles/s42003-018-0042-6.pdf |
Publication 8523
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Abstract
Risk-taking propensity is a trait of significant public health relevance but few specific genetic factors are known. Here we perform a genome-wide association study of self-reported risk-taking propensity among 436,236 white European UK Biobank study participants. We identify genome-wide associations at 26 loci (P < 5 × 10−8), 24 of which are novel, implicating genes enriched in the GABA and GABA receptor pathways. Modelling the relationship between risk-taking propensity and body mass index (BMI) using Mendelian randomisation shows a positive association (0.25 approximate SDs of BMI (SE: 0.06); P = 6.7 × 10−5). The impact of individual SNPs is heterogeneous, indicating a complex relationship arising from multiple shared pathways. We identify positive genetic correlations between risk-taking and waist-hip ratio, childhood obesity, ever smoking, attention-deficit hyperactivity disorder, bipolar disorder and schizophrenia, alongside a negative correlation with women's age at first birth. These findings highlight that behavioural pathways involved in risk-taking propensity may play a role in obesity, smoking and psychiatric disorders.</p>
10 Authors
- Emma A. D. Clifton
- John R. B. Perry
- Fumiaki Imamura
- Luca A. Lotta
- Soren Brage
- Nita G. Forouhi
- Simon J. Griffin
- Nicholas J. Wareham
- Ken K. Ong
- Felix R. Day
1 Application
| Application ID | Title |
|---|---|
| 9905 | Using genetics to elucidate the relationship between socioeconomic/behavioural traits and disease |
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