| Title: | Human longevity: 25 genetic loci associated in 389,166 UK biobank participants |
| Journal: | Aging |
| Published: | 6 Dec 2017 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/29227965/ |
| DOI: | https://doi.org/10.18632/aging.101334 |
| URL: | http://hdl.handle.net/10871/34358 |
| Citations: | 158 (31 in last 2 years) as of 8 Aug 2024 |
Publication 8501
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Abstract
We undertook a genome-wide association study (GWAS) of parental longevity in European descent UK Biobank participants. For combined mothers' and fathers' attained age, 10 loci were associated (p<5*10-8), including 8 previously identified for traits including survival, Alzheimer's and cardiovascular disease. Of these, 4 were also associated with longest 10% survival (mothers age ≥90 years, fathers ≥87 years), with 2 additional associations including MC2R intronic variants (coding for the adrenocorticotropic hormone receptor). Mother's age at death was associated with 3 additional loci (2 linked to autoimmune conditions), and 8 for fathers only. An attained age genetic risk score associated with parental survival in the US Health and Retirement Study and the Wisconsin Longitudinal Study and with having a centenarian parent (n=1,181) in UK Biobank. The results suggest that human longevity is highly polygenic with prominent roles for loci likely involved in cellular senescence and inflammation, plus lipid metabolism and cardiovascular conditions. There may also be gender specific routes to longevity.</p>
12 Keywords
- Adult
- Aged
- Biological Specimen Banks
- Female
- Genome-Wide Association Study
- Humans
- Longevity
- Male
- Middle Aged
- Multifactorial Inheritance
- Parents
- United Kingdom
10 Authors
- Luke C. Pilling
- Chia-Ling Kuo
- Kamil Sicinski
- Jone Tamosauskaite
- George A. Kuchel
- Lorna W. Harries
- Pamela Herd
- Robert Wallace
- Luigi Ferrucci
- David Melzer
1 Application
| Application ID | Title |
|---|---|
| 1417 | Associations between parental attained ages and health status |
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