| Title: | Genome-wide analysis identifies 12 loci influencing human reproductive behavior |
| Journal: | Nature Genetics |
| Published: | 31 Oct 2016 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/27798627/ |
| DOI: | https://doi.org/10.1038/ng.3698 |
| URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5695684 |
| Citations: | 257 (39 in last 2 years) as of 8 Aug 2024 |
Publication 8447
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Abstract
Melinda Mills, Nicola Barban, Harold Snieder, Marcel den Hoed and colleagues perform a meta-analysis of data from over 300,000 individuals for age at first birth and number of children ever born. They identify 12 significant loci that associate with these traits, providing insights into the genetic basis of human reproductive behavior.</p>
13 Keywords
- Birth Order
- Female
- Fertility
- Genome-Wide Association Study
- Humans
- Maternal Age
- Parity
- Phenotype
- Polymorphism, Single Nucleotide
- Pregnancy
- Quantitative Trait Loci
- Reproduction
- Reproductive Behavior
253 Authors
- Nicola Barban
- Rick Jansen
- Ronald de Vlaming
- Ahmad Vaez
- Jornt J Mandemakers
- Felix C Tropf
- Xia Shen
- James F Wilson
- Daniel I Chasman
- Ilja M Nolte
- Vinicius Tragante
- Sander W van der Laan
- John R B Perry
- Augustine Kong
- Tarunveer S Ahluwalia
- Eva Albrecht
- Laura Yerges-Armstrong
- Gil Atzmon
- Kirsi Auro
- Kristin Ayers
- Andrew Bakshi
- Danny Ben-Avraham
- Klaus Berger
- Aviv Bergman
- Lars Bertram
- Lawrence F Bielak
- Gyda Bjornsdottir
- Marc Jan Bonder
- Linda Broer
- Minh Bui
- Caterina Barbieri
- Alana Cavadino
- Jorge E Chavarro
- Constance Turman
- Maria Pina Concas
- Heather J Cordell
- Gail Davies
- Peter Eibich
- Nicholas Eriksson
- Tõnu Esko
- Joel Eriksson
- Fahimeh Falahi
- Janine F Felix
- Mark Alan Fontana
- Lude Franke
- Ilaria Gandin
- Audrey J Gaskins
- Christian Gieger
- Erica P Gunderson
- Xiuqing Guo
- Caroline Hayward
- Chunyan He
- Edith Hofer
- Hongyan Huang
- Peter K Joshi
- Stavroula Kanoni
- Robert Karlsson
- Stefan Kiechl
- Annette Kifley
- Alexander Kluttig
- Peter Kraft
- Vasiliki Lagou
- Cecile Lecoeur
- Jari Lahti
- Ruifang Li-Gao
- Penelope A Lind
- Tian Liu
- Enes Makalic
- Crysovalanto Mamasoula
- Lindsay Matteson
- Hamdi Mbarek
- Patrick F McArdle
- George McMahon
- S Fleur W Meddens
- Evelin Mihailov
- Mike Miller
- Stacey A Missmer
- Claire Monnereau
- Peter J van der Most
- Ronny Myhre
- Mike A Nalls
- Teresa Nutile
- Ioanna Panagiota Kalafati
- Eleonora Porcu
- Inga Prokopenko
- Kumar B Rajan
- Janet Rich-Edwards
- Cornelius A Rietveld
- Antonietta Robino
- Lynda M Rose
- Rico Rueedi
- Kathleen A Ryan
- Yasaman Saba
- Daniel Schmidt
- Jennifer A Smith
- Lisette Stolk
- Elizabeth Streeten
- Anke Tönjes
- Gudmar Thorleifsson
- Sheila Ulivi
- Juho Wedenoja
- Juergen Wellmann
- Peter Willeit
- Jie Yao
- Loic Yengo
- Jing Hua Zhao
- Wei Zhao
- Daria V Zhernakova
- Najaf Amin
- Howard Andrews
- Beverley Balkau
- Nir Barzilai
- Sven Bergmann
- Ginevra Biino
- Hans Bisgaard
- Klaus Bønnelykke
- Dorret I Boomsma
- Julie E Buring
- Harry Campbell
- Stefania Cappellani
- Marina Ciullo
- Simon R Cox
- Francesco Cucca
- Daniela Toniolo
- George Davey-Smith
- Ian J Deary
- George Dedoussis
- Panos Deloukas
- Cornelia M van Duijn
- Eco J C de Geus
- Johan G Eriksson
- Denis A Evans
- Jessica D Faul
- Cinzia Felicita Sala
- Philippe Froguel
- Paolo Gasparini
- Giorgia Girotto
- Hans-Jörgen Grabe
- Karin Halina Greiser
- Patrick J F Groenen
- Hugoline G de Haan
- Johannes Haerting
- Tamara B Harris
- Andrew C Heath
- Kauko Heikkilä
- Albert Hofman
- Georg Homuth
- Elizabeth G Holliday
- John Hopper
- Elina Hyppönen
- Bo Jacobsson
- Vincent W V Jaddoe
- Magnus Johannesson
- Astanand Jugessur
- Mika Kähönen
- Eero Kajantie
- Sharon L R Kardia
- Bernard Keavney
- Ivana Kolcic
- Päivikki Koponen
- Peter Kovacs
- Florian Kronenberg
- Zoltan Kutalik
- Martina La Bianca
- Genevieve Lachance
- William G Iacono
- Sandra Lai
- Terho Lehtimäki
- David C Liewald
- Cecilia M Lindgren
- Yongmei Liu
- Robert Luben
- Michael Lucht
- Riitta Luoto
- Per Magnus
- Patrik K E Magnusson
- Nicholas G Martin
- Matt McGue
- Ruth McQuillan
- Sarah E Medland
- Christa Meisinger
- Dan Mellström
- Andres Metspalu
- Michela Traglia
- Lili Milani
- Paul Mitchell
- Grant W Montgomery
- Dennis Mook-Kanamori
- Renée de Mutsert
- Ellen A Nohr
- Claes Ohlsson
- Jørn Olsen
- Ken K Ong
- Lavinia Paternoster
- Alison Pattie
- Brenda W J H Penninx
- Markus Perola
- Patricia A Peyser
- Mario Pirastu
- Ozren Polasek
- Chris Power
- Jaakko Kaprio
- Leslie J Raffel
- Katri Räikkönen
- Olli Raitakari
- Paul M Ridker
- Susan M Ring
- Kathryn Roll
- Igor Rudan
- Daniela Ruggiero
- Dan Rujescu
- Veikko Salomaa
- David Schlessinger
- Helena Schmidt
- Reinhold Schmidt
- Nicole Schupf
- Johannes Smit
- Rossella Sorice
- Tim D Spector
- John M Starr
- Doris Stöckl
- Konstantin Strauch
- Michael Stumvoll
- Morris A Swertz
- Unnur Thorsteinsdottir
- A Roy Thurik
- Nicholas J Timpson
- Joyce Y Tung
- André G Uitterlinden
- Simona Vaccargiu
- Jorma Viikari
- Veronique Vitart
- Henry Völzke
- Peter Vollenweider
- Dragana Vuckovic
- Johannes Waage
- Gert G Wagner
- Jie Jin Wang
- Nicholas J Wareham
- David R Weir
- Gonneke Willemsen
- Johann Willeit
- Alan F Wright
- Krina T Zondervan
- Kari Stefansson
- Robert F Krueger
- James J Lee
- Daniel J Benjamin
- David Cesarini
- Philipp D Koellinger
- Marcel den Hoed
- Harold Snieder
- Melinda C Mills
Enabling scientific discoveries that improve human health