| Title: | Evaluating the contribution of genetics and familial shared environment to common disease using the UK Biobank |
| Journal: | Nature Genetics |
| Published: | 18 Jul 2016 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/27428752/ |
| DOI: | https://doi.org/10.1038/ng.3618 |
| URL: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5989924 |
| Citations: | 95 (9 in last 2 years) as of 8 Aug 2024 |
Publication 8428
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Abstract
Albert Tenesa and colleagues report an analysis of the heritability of 12 complex diseases in 1,555,906 individuals from the UK Biobank. They find that SNP heritability explains a higher proportion of estimated heritability when shared familial environmental factors are taken into account.</p>
13 Keywords
- Biological Specimen Banks
- Disease
- Female
- Gene-Environment Interaction
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Male
- Models, Genetic
- Phenotype
- Polymorphism, Single Nucleotide
- Quantitative Trait, Heritable
- United Kingdom
6 Authors
- María Muñoz
- Ricardo Pong-Wong
- Oriol Canela-Xandri
- Konrad Rawlik
- Chris S Haley
- Albert Tenesa
Enabling scientific discoveries that improve human health