| Title: | Impact of Maternal Smoking, Offspring Smoking, and Genetic Susceptibility on Crohn's Disease and Ulcerative Colitis |
| Journal: | Journal of Crohn's and Colitis |
| Published: | 1 Dec 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/38038665/ |
| DOI: | https://doi.org/10.1093/ecco-jcc/jjad200 |
| Citations: | 1 (1 in last 2 years) as of 8 Aug 2024 |
Publication 8223
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Abstract
BACKGROUND AND AIMS: The long-term impact of maternal smoking during pregnancy [MSDP] on the risk of Crohn's disease [CD] and ulcerative colitis [UC] in adult offspring remains uncertain. The present study aimed to investigate the individual and combined effects of early life exposure [MSDP], offspring personal behaviour [smoking], and genetic risk on the development of CD and UC in adult offspring.</p>
METHODS: We conducted a prospective cohort study using UK Biobank data, including 334 083 participants recruited between 2006 and 2010, with follow-up until December 31, 2021. Multivariable Cox regression models were used to evaluate the associations of genetic factors, maternal and personal smoking, and their combination with CD and UC.</p>
RESULTS: Participants exposed to MSDP had an 18% increased risk of CD compared to those without MSDP (hazard ratio [HR] = 1.18, 95% confidence interval [CI] = 1.01-1.39). However, no significant association was found between MSDP and UC risk [HR = 1.03, 95% CI = 0.92-1.16]. Personal smoking increased the risk of CD and UC, and had a numerically amplified effect with MSDP. Participants with high genetic risk and MSDP had a 2.01-fold [95% CI = 1.53-2.65] and a 2.45-fold [95% CI = 2.00-2.99] increased risk of CD and UC, respectively, compared to participants without MSDP and with low genetic risk.</p>
CONCLUSIONS: Our prospective cohort study provides evidence that MSDP increases the risk of CD in adult offspring, whereas no evidence supports their causal association. Additionally, smoking and genetic susceptibility had a numerically amplified effect with MSDP on CD and UC, but the interaction lacked statistical significance.</p>
16 Authors
- Linmin Hu
- Siqing Wu
- Yuelong Shu
- Kai Su
- Chunliang Wang
- Danni Wang
- Qiangsheng He
- Xinyu Chen
- Wenjing Li
- Ningning Mi
- Peng Xie
- Jinyu Zhao
- Shiyong Zhang
- Jinqiu Yuan
- Jianbang Xiang
- Bin Xia
1 Application
| Application ID | Title |
|---|---|
| 51671 | Metabolism syndrome and risk of cancer |
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