| Title: | 15 years of GWAS discovery: Realizing the promise |
| Journal: | American Journal of Human Genetics |
| Published: | 11 Jan 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/36634672/ |
| DOI: | https://doi.org/10.1016/j.ajhg.2022.12.011 |
| Citations: | 131 (130 in last 2 years) as of 8 Aug 2024 |
Publication 7992
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
It has been 15 years since the advent of the genome-wide association study (GWAS) era. Here, we review how this experimental design has realized its promise by facilitating an impressive range of discoveries with remarkable impact on multiple fields, including population genetics, complex trait genetics, epidemiology, social science, and medicine. We predict that the emergence of large-scale biobanks will continue to expand to more diverse populations and capture more of the allele frequency spectrum through whole-genome sequencing, which will further improve our ability to investigate the causes and consequences of human genetic variation for complex traits and diseases.4 Authors
- Abdel Abdellaoui
- Loic Yengo
- Karin J H Verweij
- Peter M Visscher
1 Application
| Application ID | Title |
|---|---|
| 12505 | Dissecting the genetic basis of relationships between early-life and later-life events |
Enabling scientific discoveries that improve human health