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Abstract
PREVENTION RELEVANCE: In this prospective population-based cohort study, we show the improved performance of a new risk assessment model compared with a gold-standard model (BCRAT). The classification of at-risk women using this new model highlights the opportunity to improve risk stratification and implement existing clinical risk-reduction interventions.
Validation of polygenic risk scores, based upon pooled discovery studies, for predisposition to major prevalent diseases affecting both quality-of-life and lifespan and testing for causation.
Enabling scientific discoveries that improve human health