| Title: | Fast and accurate out-of-core PCA framework for large scale biobank data |
| Journal: | Genome Research |
| Published: | 24 Aug 2023 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/37620119/ |
| DOI: | https://doi.org/10.1101/gr.277525.122 |
| Citations: | 3 (3 in last 2 years) as of 8 Aug 2024 |
Publication 7684
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Abstract
Principal component analysis (PCA) is widely used in statistics, machine learning, and genomics for dimensionality reduction and uncovering low-dimensional latent structure. To address the challenges posed by ever-growing data size, fast and memory-efficient PCA methods have gained prominence. In this paper, we propose a novel randomized singular value decomposition (RSVD) algorithm implemented in PCAone, featuring a window-based optimization scheme that enables accelerated convergence while improving the accuracy. Additionally, PCAone incorporates out-of-core and multithreaded implementations for the existing Implicitly Restarted Arnoldi Method (IRAM) and RSVD. Through comprehensive evaluations using multiple large-scale real-world data sets in different fields, we show the advantage of PCAone over existing methods. The new algorithm achieves significantly faster computation time while maintaining accuracy comparable to the slower IRAM method. Notably, our analyses of UK Biobank, comprising around 0.5 million individuals and 6.1 million common single nucleotide polymorphisms, show that PCAone accurately computes the top 40 principal components within 9 h. This analysis effectively captures population structure, signals of selection, structural variants, and low recombination regions, utilizing <20 GB of memory and 20 CPU threads. Furthermore, when applied to single-cell RNA sequencing data featuring 1.3 million cells, PCAone, accurately capturing the top 40 principal components in 49 min. This performance represents a 10-fold improvement over state-of-the-art tools.</p>
3 Authors
- Zilong Li
- Jonas Meisner
- Anders Albrechtsen
1 Application
| Application ID | Title |
|---|---|
| 32683 | Combined effect of the genetic and lifestyle determinants of metabolic syndrome on cardiometabolic risk |
Enabling scientific discoveries that improve human health