| Title: | Genome-wide association study of corneal biomechanical properties identifies over 200 loci providing insight into the genetic etiology of ocular diseases |
| Journal: | Human Molecular Genetics |
| Published: | 27 Jul 2020 |
| Pubmed: | https://pubmed.ncbi.nlm.nih.gov/32716492/ |
| DOI: | https://doi.org/10.1093/hmg/ddaa155 |
| URL: | https://kclpure.kcl.ac.uk/portal/en/publications/9edc7c93-224a-459e-bfc2-444efedf6942 |
| Citations: | 29 (13 in last 2 years) as of 8 Aug 2024 |
Publication 7635
WARNING: the interactive features of this website use CSS3, which your browser does not support. To use the full features of this website, please update your browser.
Abstract
Corneal hysteresis and corneal resistance factor are parameters that reflect the dynamic biomechanical properties of the cornea and have been shown to be biomarkers of corneal disease. In this genome-wide association study of over 100 000 participants, we identified over 200 genetic loci, all but eight novel, significantly associated with either one or both of these traits. In addition to providing key insights into the genetic architecture underlying normal corneal function, these results identify many candidate loci in the study of corneal diseases that lead to severe visual impairment. Additionally, using Mendelian randomization, we were able to identify causal relationships between corneal biomechanics and intraocular pressure measurements, which help elucidate the relationship between corneal properties and glaucoma.</p>
14 Keywords
- Adult
- Aged
- Biomechanical Phenomena
- Corneal Diseases
- Female
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Glaucoma, Open-Angle
- Humans
- Intraocular Pressure
- Male
- Middle Aged
- R Factors
- Tonometry, Ocular
5 Authors
- Mark J Simcoe
- Anthony P Khawaja
- Pirro G Hysi
- Christopher J Hammond
- Biobank Eye and Vision Consortium
1 Application
| Application ID | Title |
|---|---|
| 17615 | Genetic contribution to vision loss and disability: The UK Biobank Eye & Vision Consortium |
Enabling scientific discoveries that improve human health